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Literature summary extracted from

  • Stein, B.; Brady, H.; Yang, M.X.; Young, D.B.; Barbosa, M.S.
    Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade (1996), J. Biol. Chem., 271, 11427-11433.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.12.2 anisomycin activates Homo sapiens
2.7.12.2 additional information MEK6 is strongly activated by UV, anisomycin, and osmotic shock Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.12.2
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.2 ATP + protein Homo sapiens MEK6 is a member of the p38 kinase cascade and efficiently phosphorylates p38, induces phosphorylation of ATF2 by p38 but does not phosphorylate ATF2 directly ADP + phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Homo sapiens P52564
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.2 ATP + p38
-
 Homo sapiens ADP + ?
-
 ?
2.7.12.2 ATP + protein MEK6 is a member of the p38 kinase cascade and efficiently phosphorylates p38, induces phosphorylation of ATF2 by p38 but does not phosphorylate ATF2 directly Homo sapiens ADP + phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 6
-
 Homo sapiens
2.7.12.2 MKK6
-
 Homo sapiens