Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Su, G.H.; Hilgers, W.; Shekher, M.C.; Tang, D.J.; Yeo, C.J.; Hruban, R.H.; Kern, S.E.
    Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene (1998), Cancer Res., 58, 2339-2342.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.2 ATP + protein Homo sapiens MKK4 may participate in a tumor suppressive signaling pathway distinct from DPC4, p16, p53, and BRCA2. The enzyme is a component of a stress and cytokine-induced signal transduction pathway involving MAPK proteins, additional role for MKK4 in tumor suppression ADP + phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Homo sapiens P45985
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.12.2 breast cancer cell line
-
 Homo sapiens
-
2.7.12.2 colonic cancer cell line colorectal cancer cell line Homo sapiens
-
2.7.12.2 lung cancer cell line
-
 Homo sapiens
-
2.7.12.2 pancreatic cancer cell line
-
 Homo sapiens
-
2.7.12.2 testicular cancer cell line human pancreatic, lung, breast, testicle, and colorectal cancer cell lines Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.2 ATP + protein MKK4 may participate in a tumor suppressive signaling pathway distinct from DPC4, p16, p53, and BRCA2. The enzyme is a component of a stress and cytokine-induced signal transduction pathway involving MAPK proteins, additional role for MKK4 in tumor suppression Homo sapiens ADP + phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 4
-
 Homo sapiens
2.7.12.2 MKK4
-
 Homo sapiens