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Literature summary extracted from

  • Duesbery, N.S.; Webb, C.P.; Leppla, S.H.; Gordon, V.M.; Klimpel, K.R.; Copeland, T.D.; Ahn, N.G.; Oskarsson, M.K.; Fukasawa, K.; Paull, K.D.; Vande Woude, G.F.
    Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor (1998), Science, 280, 734-737.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.83 E687C inactive Bacillus anthracis

General Stability

EC Number General Stability Organism
2.7.12.2 proteolytic inactivation by anthrax lethal factor Mus musculus
2.7.12.2 proteolytic inactivation by anthrax lethal factor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.2 ATP + protein Mus musculus enzyme is involved on MAPK signal transduction pathway ADP + phosphoprotein
-
 ?
2.7.12.2 ATP + protein Homo sapiens enzyme is involved on MAPK signal transduction pathway ADP + phosphoprotein
-
 ?
3.4.24.83 mitogen-activated protein kinase + H2O Bacillus anthracis inactivation of substrate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Homo sapiens P36507
-
-
2.7.12.2 Homo sapiens Q02750
-
-
2.7.12.2 Mus musculus P31938
-
-
3.4.24.83 Bacillus anthracis
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.24.83 Preferred amino acids around the cleavage site can be denoted BBBBxHx-/-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases From the bacterium Bacilus anthracis that causes anthrax. One of three proteins that are collectively termed anthrax toxin. Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases Bacillus anthracis
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.2 ATP + protein enzyme is involved on MAPK signal transduction pathway Mus musculus ADP + phosphoprotein
-
 ?
2.7.12.2 ATP + protein enzyme is involved on MAPK signal transduction pathway Homo sapiens ADP + phosphoprotein
-
 ?
3.4.24.83 mitogen-activated protein kinase + H2O substrates: MAPKK1, MAPKK2 Bacillus anthracis ?
-
 ?
3.4.24.83 mitogen-activated protein kinase + H2O inactivation of substrate Bacillus anthracis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 1
-
 Mus musculus
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 1
-
 Homo sapiens
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 2
-
 Homo sapiens
2.7.12.2 MAPKK1
-
 Mus musculus
2.7.12.2 MAPKK2
-
 Homo sapiens