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Literature summary extracted from

  • Crews, C.M.; Erikson, R.L.
    Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product (1992), Proc. Natl. Acad. Sci. USA, 89, 8205-8209.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.12.2 additional information inactivated by the serine/threonine phosphatase 2A but not by the protein-tyrosine phosphatase 1B Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Mus musculus P31938
-
-
2.7.12.2 Mus musculus Q63932
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.12.2
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.2 ATP + Erk-1 gene product phosphorylation primarily on a tyrosine residue and, to a lesser extent, on a threonine Mus musculus ADP + phosphorylated Erk-1 gene product
-
 ?
2.7.12.2 ATP + myelin basic protein kinase
-
 Mus musculus ADP + phosphorylated myelin basic protein kinase
-
 ?
2.7.12.2 ATP + protein phosphorylates kinase-inactive Erk-1 protein primarily on a tyrosine residue and, to a lesser extent, on a threonine Mus musculus ADP + phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 1
-
 Mus musculus
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 2
-
 Mus musculus
2.7.12.2 MAPK/Erk kinase
-
 Mus musculus
2.7.12.2 MEK
-
 Mus musculus