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Literature summary extracted from

  • Moriguchi, T.; Toyoshima, F.; Gotoh, Y.; Iwamatsu, A.; et al.
    Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2 (1996), J. Biol. Chem., 271, 26981-26988.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.12.2 expressed in COS7 cells Mus musculus
2.7.12.2 expressed in COS7 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.2 ATP + protein Mus musculus enzyme is the major activator for p38 ADP + phosphoprotein
-
 ?
2.7.12.2 ATP + protein Homo sapiens enzyme is the major activator for p38 ADP + phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Homo sapiens P46734
-
-
2.7.12.2 Mus musculus O09110
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.12.2 L-5178-Y cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.2 ATP + protein enzyme is the major activator for p38 Mus musculus ADP + phosphoprotein
-
 ?
2.7.12.2 ATP + protein enzyme is the major activator for p38 Homo sapiens ADP + phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 3
-
 Mus musculus
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 3
-
 Homo sapiens