Literature summary extracted from

Seger, R.; Ahn, N.G.; Boulton, T.G.; Yancopoulos, G.D.; Panayotatos, N.; Radziejewska, E.; Ericsson, L.; Bratlien, R.L.; Cobb, M.H.; Krebs, E.G.
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation (1991), Proc. Natl. Acad. Sci. USA, 88, 6142-6146.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.11.24	Rattus norvegicus	P21708	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.11.24	ATP + protein	autophosphorylation on both tyrosine and threonine residues, autophosphorylation is probably involved in the MAP kinase activation process in vitro, but it may not be sufficient for full activation	Rattus norvegicus	ADP + phosphoprotein	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.11.24	mitogen-activated protein kinase 3	-	Rattus norvegicus

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Release 2023.1 (January 2023)