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Literature summary extracted from

  • Garcia, J.G.N.; Lazar, V.; Gilbert-McClain, L.I.; Gallagher, P.J.; Verin, A.D.
    Myosin light chain kinase in endothelium: molecular cloning and regulation (1997), Am. J. Respir. Cell Mol. Biol., 16, 489-494.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.18
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.18 211000
-
 deduced from nucleotide sequence Homo sapiens
2.7.11.18 214000
-
 1 * 214000, SDS-PAGE, endothelial enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Homo sapiens phosphorylation of myosin light chains by myosin light chain kinase is a key event in agonist-mediated endothelial cell gap formation and vascular permeability ADP + phosphorylated myosin light chain
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Bos taurus
-
-
-
2.7.11.18 Homo sapiens
-
-
-
2.7.11.18 Homo sapiens Q15746
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 endothelium
-
 Homo sapiens
-
2.7.11.18 endothelium
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain phosphorylation of myosin light chains by myosin light chain kinase is a key event in agonist-mediated endothelial cell gap formation and vascular permeability Homo sapiens ADP + phosphorylated myosin light chain
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.18 monomer
-
 Bos taurus
2.7.11.18 monomer 1 * 214000, SDS-PAGE, endothelial enzyme Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
 Homo sapiens
2.7.11.18 myosin light chain kinase
-
 Homo sapiens