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Literature summary extracted from

  • Sallese, M.; Mariggio, S.; Collodel, G.; Moretti, E.; Piomboni, P.; Baccetti, B.; De Blasi, A.
    G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells (1997), J. Biol. Chem., 272, 10188-10195.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.16 Calmodulin reaction of isoenzyme GRK4alpha with rhodopsin, IC50: 80 nM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.16 additional information Homo sapiens enzyme is involved in fertilization ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.16 Homo sapiens P32298 4 isoforms: GRK4alpha, GRK4beta, GRK4gamma, GRK4delta
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.16 cell culture spermatogonia cell line GC-1 spg Homo sapiens
-
2.7.11.16 germ
-
 Homo sapiens
-
2.7.11.16 sperm GRK4gamma is the only detectable isoform in human sperm Homo sapiens
-
2.7.11.16 spermatozoon
-
 Homo sapiens
-
2.7.11.16 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.16 ATP + rhodopsin reaction only with GRK4alpha isoform, no reaction with GRK4beta, GRK4gamma, GRK4delta Homo sapiens ADP + phosphorylated rhodopsin
-
 ?
2.7.11.16 additional information enzyme is involved in fertilization Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.16 G protein-coupled receptor kinase GRK4
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.16 0.00008
-
 reaction of isoenzyme GRK4alpha with rhodopsin, IC50: 80 nM Homo sapiens Calmodulin