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Literature summary extracted from

  • Delcommenne, M.; Tan, C.; Gray, V.; Rue, L.; Woodgett, J.; Dedhar, S.
    Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase (1998), Proc. Natl. Acad. Sci. USA, 95, 11211-11216.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 additional information ILK activity is rapidly, but transiently, stimulated upon attachment of cells to fibronectin, as well as by insulin, in a phosphoinositide-3-OH kinase-dependent manner. Furthermore, phosphatidylinositol(3,4,5)trisphosphate specifically stimulates the activity of ILK in vitro, and in addition, membrane targeted constitutively active Pi(3)K activates ILK in vivo Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a protein Homo sapiens ILK is involved in agonist stimulated, Pi(3)K-dependent, PKB/AKT activation. ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3 ADP + a phosphoprotein
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens Q13418
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-
2.7.11.1 Homo sapiens P31749
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-
2.7.11.26 Homo sapiens P49841
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a protein ILK is involved in agonist stimulated, Pi(3)K-dependent, PKB/AKT activation. ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3 Homo sapiens ADP + a phosphoprotein
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 ?
2.7.11.26 glycogen synthase + ATP
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 Homo sapiens phosphorylated glycogen synthase + ADP
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 integrin-linked protein kinase 1
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 Homo sapiens
2.7.11.1 RAC-alpha serine/threonine kinase
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 Homo sapiens
2.7.11.26 glycogen synthase kinase-3 alpha
-
 Homo sapiens