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Literature summary extracted from

  • Palczewski, K.; Buczylko, J.; Van Hooser, P.; Carr, S.A.; Huddleston, M.J.; Crabb, J.W.
    Identification of the autophosphorylation sites in rhodopsin kinase (1992), J. Biol. Chem., 267, 18991-18998.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.14 rhodopsin activates Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.14 additional information not inhibited by a synthetic peptide corresponding to the major or minor autophosphorylation site of RK Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.14 membrane rod membranes Bos taurus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.14 Mg2+
-
Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.14 65000
-
x * 65000, dephosphorylated RK, SDS-PAGE Bos taurus
2.7.11.14 66000
-
x * 66000, autophosphorylated RK, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.14 ATP + rhodopsin Bos taurus second messenger-independent protein kinase, involved in the deactivation of photolyzed rhodopsin ADP + phosphorhodopsin
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.14 Bos taurus
-
-
-
2.7.11.14 Bos taurus P28327
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.14 additional information putative posttranslational modification sites: C-terminal isoprenylation, N-terminal myristoylation Bos taurus
2.7.11.14 phosphoprotein autophosphorylation sites of RK, major sites are Ser-488 and Thr-489, minor site is Ser-21 Bos taurus
2.7.11.14 phosphoprotein autophosphorylation may lower the affinity of RK for photoactivated rhodopsin via repulsion between phosphorylated sites on photoactivated rhodopsin and RK Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.14
-
Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.14 eye retina Bos taurus
-
2.7.11.14 retina rod cell outer segment Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.14 0.555
-
pH 7.5 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.14 ATP + peptide low catalytic efficiency of RK toward a peptide containing its major autophosphorylation site Bos taurus ADP + phosphopeptide
-
?
2.7.11.14 ATP + protein autophosphorylation Bos taurus ADP + phosphoprotein
-
?
2.7.11.14 ATP + rhodopsin highly specific for photobleached rhodopsin Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin high-gain phosphorylation of rhodopsin Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin domain structure Bos taurus ADP + phosphorhodopsin
-
?
2.7.11.14 ATP + rhodopsin second messenger-independent protein kinase, involved in the deactivation of photolyzed rhodopsin Bos taurus ADP + phosphorhodopsin
-
?

Subunits

EC Number Subunits Comment Organism
2.7.11.14 ? x * 66000, autophosphorylated RK, SDS-PAGE Bos taurus
2.7.11.14 ? x * 65000, dephosphorylated RK, SDS-PAGE Bos taurus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.14 rhodopsin kinase
-
Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.14 30
-
assay at Bos taurus
2.7.11.14 30
-
peptide assay Bos taurus