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Literature summary extracted from

  • Cisek, L.J.; Corden, J.L.
    Purification of protein kinases that phosphorylate the repetitive carboxyl-terminal domain of eukaryotic RNA polymerase II (1991), Methods Enzymol., 200, 301-325.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.7.11.23 purified mouse enzymes are rather unstable with a half-life of several days, bovine serum albumin does not stabilize Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.23 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole nucleotide analog Homo sapiens
2.7.11.23 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole nucleotide analog Mus musculus
2.7.11.23 High salt concentrations above 250 mM Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.23 0.03
-
ATP
-
Homo sapiens
2.7.11.23 0.03
-
ATP 30°C, pH 7.9 Mus musculus
2.7.11.23 0.18
-
GTP 30°C, pH 7.9 Mus musculus
2.7.11.23 0.189
-
hepta-six peptide 30°C, pH 7.9 Mus musculus
2.7.11.23 0.2
-
hepta-six peptide 30°C, pH 7.9 Mus musculus
2.7.11.23 0.212
-
L-Arg-hepta peptide 30°C, pH 7.9 Mus musculus
2.7.11.23 0.243
-
L-Arg-hepta peptide 30°C, pH 7.9 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.23 Mg2+ requirement Mus musculus
2.7.11.23 Mg2+ requirement Homo sapiens
2.7.11.23 Mg2+ requirement Saccharomyces cerevisiae
2.7.11.23 Mg2+ requirement Triticum aestivum
2.7.11.23 Mg2+ 10 mM Mus musculus
2.7.11.23 Mg2+ 10 mM Homo sapiens
2.7.11.23 Mn2+ activation Mus musculus
2.7.11.23 Mn2+ activation Triticum aestivum
2.7.11.23 additional information no activation by Ca2+ Mus musculus
2.7.11.23 additional information no activation by Ca2+ Saccharomyces cerevisiae
2.7.11.23 additional information no activation by Ca2+ Triticum aestivum
2.7.11.23 additional information no activation by Cu2+ and Zn2+ Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] Mus musculus presumably obligate part of transcription process ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] Homo sapiens presumably obligate part of transcription process ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] Saccharomyces cerevisiae presumably obligate part of transcription process ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] Triticum aestivum presumably obligate part of transcription process ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.23 Homo sapiens
-
-
-
2.7.11.23 Mus musculus
-
-
-
2.7.11.23 Saccharomyces cerevisiae
-
baker's yeast
-
2.7.11.23 Triticum aestivum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.23 two kinases: cdc2/p58 and cdc2/p62 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.23 cell culture
-
Mus musculus
-
2.7.11.23 cell culture
-
Homo sapiens
-
2.7.11.23 cell culture
-
Saccharomyces cerevisiae
-
2.7.11.23 Ehrlich ascites carcinoma cell
-
Mus musculus
-
2.7.11.23 germ
-
Triticum aestivum
-
2.7.11.23 HeLa cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.23 1.238
-
after second phenyl-superose chromatography Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.23 ATP + hepta-six peptide
-
Mus musculus ADP + phosphorylated hepta-six peptide
-
?
2.7.11.23 ATP + histone H1
-
Mus musculus ADP + phosphohistone H1
-
?
2.7.11.23 ATP + L-Arg-hepta peptide
-
Mus musculus ADP + phosphorylated L-Arg-hepta peptide
-
?
2.7.11.23 ATP + synthetic peptides
-
Homo sapiens ADP + ?
-
?
2.7.11.23 ATP + synthetic peptides
-
Triticum aestivum ADP + ?
-
?
2.7.11.23 ATP + synthetic peptides hepta-six or Arg-hepta Mus musculus ADP + ?
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] no substrates are dTTP and AMP-PNP Mus musculus ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] phosphorylates predominantly Ser-residues Homo sapiens ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] phosphorylates predominantly Ser-residues Saccharomyces cerevisiae ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] phosphorylates predominantly Ser-residues Triticum aestivum ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] no substrates are CTP and UTP Mus musculus ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] no substrates are CTP and UTP Triticum aestivum ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] presumably obligate part of transcription process Mus musculus ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] presumably obligate part of transcription process Homo sapiens ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] presumably obligate part of transcription process Saccharomyces cerevisiae ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] presumably obligate part of transcription process Triticum aestivum ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
?
2.7.11.23 GTP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
-
Mus musculus GDP + ?
-
?

Subunits

EC Number Subunits Comment Organism
2.7.11.23 More
-
Saccharomyces cerevisiae
2.7.11.23 More enzymes from mouse consist of 2 components each: cdc2/p58: a cdc2 kinase (p34) and a p58 subunit, cdc2/p62: a cdc2 kinase and a p62 subunit (cyclin B), the latter is also called M phase-specific histone H1 kinase Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.23 7 8.2
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.23 additional information
-
Saccharomyces cerevisiae
2.7.11.23 additional information
-
Triticum aestivum
2.7.11.23 additional information no activation by cyclic nucleotides, phospholipids Mus musculus