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Literature summary extracted from

  • Kemp, B.E.; Parker, M.W.; Hu, S.; Tiganis, T.; House, C.
    Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity (1994), Trends Biochem. Sci., 19, 440-444.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.1 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.13 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.14 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.15 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.17 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.18 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.19 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.22 cyclin dependent on Mammalia
2.7.11.22 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.24 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.11.18 twitchin kinase, bilobal structure analysis Mammalia
2.7.11.22 bilobal structure analysis Mammalia
2.7.11.24 bilobal structure analysis Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.13 additional information the enzyme is inhibited by its regulatory subunit masking the active site, autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.14 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.15 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.17 additional information the enzyme is inhibited by its regulatory subunit masking the active site, autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.18 additional information the enzyme is inhibited by its regulatory subunit masking the active site, autoregulation by a pseudosubstrate mechanism, protein substrate-pseudosubstrate interactions, overview Mammalia
2.7.11.18 protein kinase inhibitor PKI
-
 Mammalia
2.7.11.19 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.22 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia
2.7.11.24 additional information autoregulation by a pseudosubstrate mechanism, overview Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.1 membrane
-
 Mammalia 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.1 Mg2+
-
 Mammalia
2.7.11.13 Mg2+
-
 Mammalia
2.7.11.14 Mg2+
-
 Mammalia
2.7.11.15 Mg2+
-
 Mammalia
2.7.11.17 Ca2+ binding required for activity Mammalia
2.7.11.18 Mg2+
-
 Mammalia
2.7.11.19 Mg2+
-
 Mammalia
2.7.11.22 Mg2+
-
 Mammalia
2.7.11.24 Mg2+
-
 Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?
2.7.11.13 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?
2.7.11.14 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?
2.7.11.15 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?
2.7.11.17 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?
2.7.11.18 ATP + myosin light chain Mammalia
-
 ADP + phosphorylated myosin light chain
-
 ?
2.7.11.19 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?
2.7.11.22 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?
2.7.11.24 ATP + a protein Mammalia
-
 ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Mammalia
-
-
-
2.7.11.13 Mammalia
-
-
-
2.7.11.14 Mammalia
-
-
-
2.7.11.15 Mammalia
-
-
-
2.7.11.17 Mammalia
-
-
-
2.7.11.18 Mammalia
-
-
-
2.7.11.19 Mammalia
-
-
-
2.7.11.22 Mammalia
-
-
-
2.7.11.24 Mammalia
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.1 phosphoprotein autophosphorylation, the site often depends more on structure than on primary sequence Mammalia
2.7.11.14 phosphoprotein autophosphorylation, the site often depends more on structure than on primary sequence Mammalia
2.7.11.15 phosphoprotein autophosphorylation, the site often depends more on structure than on primary sequence Mammalia
2.7.11.19 phosphoprotein autophosphorylation, the site often depends more on structure than on primary sequence Mammalia

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 skeletal muscle
-
 Mammalia
-
2.7.11.18 smooth muscle
-
 Mammalia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
2.7.10.1 additional information substrate recognition and binding structure, the enzyme depends on basic residues for substrate recognition, substrate specificity determinants in substrates Mammalia ?
-
 ?
2.7.11.13 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.13 additional information the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview Mammalia ?
-
 ?
2.7.11.14 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.14 ATP + a protein the phosphorylase kinase phosphorylates proteins and proteolytic fragments thereof, phosphorylation of multiple residues in the substrate sequence Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.14 additional information substrate specificity, the enzyme depends on basic residues for substrate recognition, the residues at the substrate phosphorylation site greatly influence the enzyme activity, autoregulation by a pseudosubstrate mechanism, overview Mammalia ?
-
 ?
2.7.11.15 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.15 ATP + a protein the phosphorylase kinase phosphorylates proteins and proteolytic fragments thereof, phosphorylation of multiple residues in the substrate sequence Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.15 additional information substrate specificity, the enzyme depends on basic residues for substrate recognition, the residues at the substrate phosphorylation site greatly influence the enzyme activity, autoregulation by a pseudosubstrate mechanism, overview Mammalia ?
-
 ?
2.7.11.17 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.17 additional information substrate specificity and binding structure, the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview Mammalia ?
-
 ?
2.7.11.18 ATP + myosin light chain
-
 Mammalia ADP + phosphorylated myosin light chain
-
 ?
2.7.11.18 additional information substrate specificity and binding structure, the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview Mammalia ?
-
 ?
2.7.11.19 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.19 ATP + a protein the phosphorylase kinase phosphorylates proteins and proteolytic fragments thereof, phosphorylation of multiple residues in the substrate sequence by mammary gland casein kinase Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.19 additional information substrate specificity, the enzyme depends on basic residues for substrate recognition, overview, the residues at the substrate phosphorylation site greatly influence the enzyme activity, autoregulation by a pseudosubstrate mechanism, overview Mammalia ?
-
 ?
2.7.11.22 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.22 additional information the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview Mammalia ?
-
 ?
2.7.11.24 ATP + a protein
-
 Mammalia ADP + a phosphoprotein
-
 ?
2.7.11.24 additional information the enzyme depends on basic residues for substrate recognition, autoregulation by a pseudosubstrate mechanism, overview Mammalia ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 insulin-receptor tyrosine kinase
-
 Mammalia
2.7.11.13 PKC
-
 Mammalia
2.7.11.17 CaMKII
-
 Mammalia
2.7.11.18 MLCK
-
 Mammalia
2.7.11.18 Twitchin kinase
-
 Mammalia
2.7.11.22 CDK
-
 Mammalia
2.7.11.24 MAPK
-
 Mammalia

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.1 ATP
-
 Mammalia
2.7.11.13 ATP
-
 Mammalia
2.7.11.14 ATP
-
 Mammalia
2.7.11.15 ATP
-
 Mammalia
2.7.11.17 ATP
-
 Mammalia
2.7.11.17 Calmodulin binding required for activity Mammalia
2.7.11.18 ATP
-
 Mammalia
2.7.11.19 ATP
-
 Mammalia
2.7.11.22 ATP
-
 Mammalia
2.7.11.24 ATP
-
 Mammalia