BRENDA - Enzyme Database

Phosphorylation of tau proteins to a state like that in Alzheimers brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids

Baudier, J.; Cole, R.D.; J. Biol. Chem. 262, 17577-17583 (1987)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.11.17
phosphatidic acid
activating at low concentrations, inhibitory at high concentrations
Rattus norvegicus
2.7.11.17
phosphatidylethanolamine
activation
Rattus norvegicus
2.7.11.17
phosphatidylserine
activation, addition leads to 100% phosphorylation of tau2-protein
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.11.17
phosphatidic acid
at high concentrations, activates at low concentrations
Rattus norvegicus
2.7.11.17
phosphatidylinositol
strong
Rattus norvegicus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.11.17
Ca2+
requirement
Rattus norvegicus
2.7.11.17
Ca2+
requirement
Bos taurus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.7.11.17
50000
-
x * 50000 + x * 60000, SDS-PAGE
Bos taurus
2.7.11.17
50000
-
x * 50000 + x * 60000, SDS-PAGE
Rattus norvegicus
2.7.11.17
60000
-
x * 50000 + x * 60000, SDS-PAGE
Bos taurus
2.7.11.17
60000
-
x * 50000 + x * 60000, SDS-PAGE
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.11.17
Bos taurus
-
-
-
2.7.11.17
Rattus norvegicus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.7.11.17
-
Bos taurus
2.7.11.17
-
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.11.17
brain
-
Bos taurus
-
2.7.11.17
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.11.17
ATP + microtubule-associated protein tau
Ca2+/calmodulin dependent autophosphorylation
490759
Rattus norvegicus
?
-
-
-
-
2.7.11.17
ATP + microtubule-associated protein tau
Ca2+/calmodulin dependent autophosphorylation
490759
Bos taurus
?
-
-
-
-
2.7.11.17
ATP + microtubule-associated protein tau
all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation
490759
Rattus norvegicus
?
-
-
-
-
2.7.11.17
ATP + microtubule-associated protein tau
all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation
490759
Bos taurus
?
-
-
-
-
Subunits
EC Number
Subunits
Commentary
Organism
2.7.11.17
?
x * 50000 + x * 60000, SDS-PAGE
Bos taurus
2.7.11.17
?
x * 50000 + x * 60000, SDS-PAGE
Rattus norvegicus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.11.17
Calmodulin
requirement
Rattus norvegicus
2.7.11.17
Calmodulin
requirement
Bos taurus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.11.17
phosphatidic acid
activating at low concentrations, inhibitory at high concentrations
Rattus norvegicus
2.7.11.17
phosphatidylethanolamine
activation
Rattus norvegicus
2.7.11.17
phosphatidylserine
activation, addition leads to 100% phosphorylation of tau2-protein
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.11.17
Calmodulin
requirement
Rattus norvegicus
2.7.11.17
Calmodulin
requirement
Bos taurus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.11.17
phosphatidic acid
at high concentrations, activates at low concentrations
Rattus norvegicus
2.7.11.17
phosphatidylinositol
strong
Rattus norvegicus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.11.17
Ca2+
requirement
Rattus norvegicus
2.7.11.17
Ca2+
requirement
Bos taurus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.7.11.17
50000
-
x * 50000 + x * 60000, SDS-PAGE
Bos taurus
2.7.11.17
50000
-
x * 50000 + x * 60000, SDS-PAGE
Rattus norvegicus
2.7.11.17
60000
-
x * 50000 + x * 60000, SDS-PAGE
Bos taurus
2.7.11.17
60000
-
x * 50000 + x * 60000, SDS-PAGE
Rattus norvegicus
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.7.11.17
-
Bos taurus
2.7.11.17
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.11.17
brain
-
Bos taurus
-
2.7.11.17
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.11.17
ATP + microtubule-associated protein tau
Ca2+/calmodulin dependent autophosphorylation
490759
Rattus norvegicus
?
-
-
-
-
2.7.11.17
ATP + microtubule-associated protein tau
Ca2+/calmodulin dependent autophosphorylation
490759
Bos taurus
?
-
-
-
-
2.7.11.17
ATP + microtubule-associated protein tau
all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation
490759
Rattus norvegicus
?
-
-
-
-
2.7.11.17
ATP + microtubule-associated protein tau
all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation
490759
Bos taurus
?
-
-
-
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.7.11.17
?
x * 50000 + x * 60000, SDS-PAGE
Bos taurus
2.7.11.17
?
x * 50000 + x * 60000, SDS-PAGE
Rattus norvegicus