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Literature summary extracted from

  • Proschel, C.; Blouin, M.J.; Gutowski, N.J.; Ludwig, R.; Noble, M.
    Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro (1995), Oncogene, 11, 1271-1281.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 located at the distal end of mouse chromosome 5 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.1 additional information mutation of residue D460 within the IHRDL motif abolishes kinase activity Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + protein Mus musculus GST-Limk1-fusion protein can autophosphorylate on serine, tyrosine and threonine residues in vitro ADP + protein tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Mus musculus P53668
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein GST-Limk1-fusion protein can autophosphorylate on serine, tyrosine and threonine residues in vitro Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 brain
-
 Mus musculus
-
2.7.11.1 nervous system high expression levels in the spinal cord and the cranial nerve and dorsal root ganglia Mus musculus
-
2.7.11.1 spinal cord
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + protein GST-Limk1-fusion protein can autophosphorylate on serine, tyrosine and threonine residues in vitro Mus musculus ADP + protein tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 LIM domain kinase 1
-
 Mus musculus