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Literature summary extracted from

  • Edwards, D.C.; Gill, G.N.
    Structural features of LIM kinase that control effects on the actin cytoskeleton (1999), J. Biol. Chem., 274, 11352-11361.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.1 additional information replacement of Thr508 with 2 glutamic acid residues results in a fully active enzyme Homo sapiens
2.7.11.1 T508V activity is abolished Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + protein Homo sapiens phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes ADP + protein tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Homo sapiens P53667
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein phosphorylation is an essential regulatory feature of LIM kinase, threonine 508 and the adjacent basic insert sequences of the activation loop are required for this process Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + protein phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes Homo sapiens ADP + protein tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 LIM domain kinase 1
-
 Homo sapiens