Literature summary extracted from

Flores-Riveros, J.R.; Sibley, E.; Kastelic, T.; Lane, M.D.
Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit (1989), J. Biol. Chem., 264, 21557-21572.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.10.1	Mus musculus	P15208	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
2.7.10.1	phosphoprotein	insulin stimulates sequential autophosphorylation of Tyr 1148, Tyr1152 and Tyr1153. Transition from the doubly to the triply phosphorylated forms is primarily responsible for the activation of substrate phosphorylation	Mus musculus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.10.1	ATP + protein tyrosine	insulin stimulates sequential autophosphorylation of Tyr1148, Tyr1152 and Tyr1153. Transition from the doubly to the triply phosphorylated forms is primarily responsible for the activation of substrate phosphorylation	Mus musculus	ADP + protein tyrosine phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.10.1	insulin receptor	-	Mus musculus

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Release 2023.1 (January 2023)