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Literature summary extracted from

  • Meissner, P.; Adams, P.; Kirsch, R.
    Allosteric inhibition of human lymphoblast and purified porphobilinogen deaminase by protoporphyrinogen and coproporphyrinogen (1993), J. Clin. Invest., 91, 1436-1444.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.61 Coproporphyrinogen
-
 Homo sapiens
2.5.1.61 protoporphyrinogen inhibits both erythroid and lymphoblast forms of the enzyme Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.61 0.0081
-
 porphobilinogen lymphoblast enzyme from control subjects Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.61 41200
-
 1 * 41200, SDS-PAGE, erythrocyte enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.61 porphobilinogen Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.61 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.61 lymphoblast variegate porphyria lymphoblasts Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.61 additional information
-
 enzyme activity in lymphoblasts from variegate porphyria subjects Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Homo sapiens uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O
-
 Homo sapiens hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 porphobilinogen
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.61 monomer 1 * 41200, SDS-PAGE, erythrocyte enzyme Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.5.1.61 PBG-deaminase
-
 Homo sapiens
2.5.1.61 uroporphyrinogen I synthetase
-
 Homo sapiens