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Literature summary extracted from

  • Russell, C.S.; Rockwell, P.
    The effects of sulfhydryl reagents on the activity of wheat germ uroporphyrinogen I synthase (1980), FEBS Lett., 116, 199-202.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.61 Hg2+ inhibition by mercury derivates of porphobilinogen, i.e. PBG-Hg, and opsopyrroledicarboxylic acid, i.e. OPD-Hg, is enhanced by porphobilinogen; opsopyrroledicarboxylic acid enhances inhibition by HgCl2 Triticum aestivum
2.5.1.61 additional information effects of sulfhydryl reagents Triticum aestivum
2.5.1.61 N-ethylmaleimide
-
 Triticum aestivum
2.5.1.61 opsopyrroledicarboxylic acid i.e. OPD, competitive Triticum aestivum
2.5.1.61 p-hydroxymercuribenzoate i.e. PHMB, inhibition is enhanced by porphobilinogen Triticum aestivum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.61 porphobilinogen Triticum aestivum
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.61 Triticum aestivum
-
 wheat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.61 germ
-
 Triticum aestivum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Triticum aestivum uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O PBG Triticum aestivum hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 porphobilinogen
-
 Triticum aestivum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.61 UPGI-S
-
 Triticum aestivum
2.5.1.61 urogenI synthase
-
 Triticum aestivum