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Literature summary extracted from

  • Agnew, W.S.; Popjak, G.
    Squalene synthetase. Stoichiometry and kinetics of presqualene pyrophosphate and squalene synthesis by yeast microsomes (1978), J. Biol. Chem., 253, 4566-4573.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.21 NADPH stimulates Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.21 membrane
-
Saccharomyces cerevisiae 16020
-
2.5.1.21 microsome
-
Saccharomyces cerevisiae
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.21 Saccharomyces cerevisiae
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.5.1.21 2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+ enzyme also catalyses the reduction of presqualene diphosphate by NADPH to squalene Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.21 farnesyl diphosphate + farnesyl diphosphate
-
Saccharomyces cerevisiae diphosphate + presqualene diphosphate
-
?
2.5.1.21 presqualene diphosphate + NAD(P)H
-
Saccharomyces cerevisiae squalene + NAD(P)+ + diphosphate
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.21 NADH
-
Saccharomyces cerevisiae
2.5.1.21 NADPH
-
Saccharomyces cerevisiae