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Literature summary extracted from

  • Leppla, S.H.; Martin, O.C.; Muehl, L.A.
    The exotoxin P. aeruginosa: a proenzyme having an unusual mode of activation (1978), Biochem. Biophys. Res. Commun., 81, 532-538.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.36 2-mercaptoethanol activation, together with SDS or guanidine hydrochloride Pseudomonas aeruginosa
2.4.2.36 cysteine activation, together with SDS or guanidine hydrochloride Pseudomonas aeruginosa
2.4.2.36 dithiothreitol enhances activity together with urea Pseudomonas aeruginosa
2.4.2.36 guanidine hydrochloride enhances activity together with dithiothreitol, cysteine, 2-mercaptoethanol or sulfite Pseudomonas aeruginosa
2.4.2.36 additional information exotoxin is synthesized in a catalytically inactive, proenzyme form, unfolding of the toxin molecule may cause activation Pseudomonas aeruginosa
2.4.2.36 SDS enhances activity together with dithiothreitol, cysteine, 2-mercaptoethanol or sulfite Pseudomonas aeruginosa
2.4.2.36 sulfite activation, together with SDS or guanidine hydrochloride Pseudomonas aeruginosa
2.4.2.36 Urea enhances activity together with dithiothreitol Pseudomonas aeruginosa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.36 extracellular exotoxin A Pseudomonas aeruginosa
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-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.36 NAD+ + elongation factor 2 Pseudomonas aeruginosa NAD-glycohydrolase activity without acceptor substrate nicotinamide + ADPribose-elongation factor 2
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Organism

EC Number Organism UniProt Comment Textmining
2.4.2.36 Pseudomonas aeruginosa
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.36 culture supernatant
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Pseudomonas aeruginosa
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.36 NAD+ + elongation factor 2 NAD-glycohydrolase activity without acceptor substrate Pseudomonas aeruginosa nicotinamide + ADPribose-elongation factor 2
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