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Literature summary extracted from

  • Itoh, R.; Holmes, E.W.; Wyngaarden, J.B.
    Pigeon liver amidophosphoribosyltransferase. Ligand-induced alterations in molecular and kinetic properties (1976), J. Biol. Chem., 251, 2234-2240.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.14 additional information complex allosteric enzyme whose activity is regulated by a series of conformational changes induced by a number of ligands Columba livia

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.14 additional information
-
additional information kinetic study Columba livia

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.14 additional information
-
the smaller molecular weight form of the liver enzyme is observed when incubated with purine nucleotides, the smaller one when incubated with phosphoribosyldiphosphate Columba livia
2.4.2.14 102000
-
sedimentation equilibrium centrifugation, phosphate, phosphoribosyldiphosphate or purine mononucleotides influence the sedimentation profile Columba livia
2.4.2.14 172000
-
sedimentation equilibrium centrifugation in the presence of phosphoribosyldiphosphate, the sedimentation profile is influenced by phosphate, phosphoribosyldiphosphate or purine mononucleotides Columba livia
2.4.2.14 181000
-
sedimentation equilibrium centrifugation in the presence of phosphate, the sedimentation profile is influenced by phosphate, phosphoribosyldiphosphate or purine mononucleotides Columba livia

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.14 Columba livia
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.14 partial Columba livia

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.14 liver
-
Columba livia
-

Storage Stability

EC Number Storage Stability Organism
2.4.2.14 2-mercaptoethanol and phosphoribosyldiphosphate stabilize during storage at 4°C Columba livia
2.4.2.14 4°C, in phosphate buffer, pH 7.4, 60 mM 2-mercaptoethanol and phosphoribosyldiphosphate, at least 10 days Columba livia
2.4.2.14 phosphate stabilizes during storage Columba livia
2.4.2.14 storage in 25 mM Tris buffer inactivates with 26% or 4% residual activity after 6 or 10 days, respectively Columba livia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.14 L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
Columba livia 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate
-
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