BRENDA - Enzyme Database show

End product inhibition of the activity of nicotinamide phosphoribosyltransferase from various tissues of rats by NAD

Shibata, K.; Taguchi, H.; Nishitani, H.; Okumura, K.; Shimabayashi, Y.; Matsushita, N.; Yamazaki, H.; Agric. Biol. Chem. 53, 2283-2284 (1989)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
NAD+
1 mM, 50%-90% inhibition in various tissues, at 0.2 mM not inhibitory in lung and liver; strong (thigh muscle)
Rattus norvegicus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.4.2.12
Mg2+
requirement
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Rattus norvegicus
-
nicotinamide D-ribonucleotide + diphosphate
-
Rattus norvegicus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.12
Rattus norvegicus
-
male Sprague-Dawley
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
brain
-
Rattus norvegicus
-
2.4.2.12
heart
-
Rattus norvegicus
-
2.4.2.12
kidney
-
Rattus norvegicus
-
2.4.2.12
liver
-
Rattus norvegicus
-
2.4.2.12
lung
-
Rattus norvegicus
-
2.4.2.12
additional information
tissue distribution
Rattus norvegicus
-
2.4.2.12
pancreas
-
Rattus norvegicus
-
2.4.2.12
small intestine
-
Rattus norvegicus
-
2.4.2.12
stomach
-
Rattus norvegicus
-
2.4.2.12
testis
-
Rattus norvegicus
-
2.4.2.12
thigh muscle
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
489741
Rattus norvegicus
nicotinamide D-ribonucleotide + diphosphate
-
489741
Rattus norvegicus
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.4.2.12
37
-
assay at
Rattus norvegicus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.4.2.12
ATP
requirement
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.4.2.12
ATP
requirement
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
NAD+
1 mM, 50%-90% inhibition in various tissues, at 0.2 mM not inhibitory in lung and liver; strong (thigh muscle)
Rattus norvegicus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.4.2.12
Mg2+
requirement
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Rattus norvegicus
-
nicotinamide D-ribonucleotide + diphosphate
-
Rattus norvegicus
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
brain
-
Rattus norvegicus
-
2.4.2.12
heart
-
Rattus norvegicus
-
2.4.2.12
kidney
-
Rattus norvegicus
-
2.4.2.12
liver
-
Rattus norvegicus
-
2.4.2.12
lung
-
Rattus norvegicus
-
2.4.2.12
additional information
tissue distribution
Rattus norvegicus
-
2.4.2.12
pancreas
-
Rattus norvegicus
-
2.4.2.12
small intestine
-
Rattus norvegicus
-
2.4.2.12
stomach
-
Rattus norvegicus
-
2.4.2.12
testis
-
Rattus norvegicus
-
2.4.2.12
thigh muscle
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
489741
Rattus norvegicus
nicotinamide D-ribonucleotide + diphosphate
-
489741
Rattus norvegicus
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.4.2.12
37
-
assay at
Rattus norvegicus