BRENDA - Enzyme Database show

Inhibition of nicotinamide phosphoribosyltransferase by pyridine nucleotides

Dietrich, L.S.; Muniz, O.; Biochemistry 11, 1691-1695 (1972)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
3-acetylpyridine
weak, kinetics
Rattus norvegicus
2.4.2.12
3-acetylpyridine adenine dinucleotide
kinetics
Rattus norvegicus
2.4.2.12
5-Fluoronicotinamide
weak, kinetics
Rattus norvegicus
2.4.2.12
6-aminonicotinamide
weak, kinetics
Rattus norvegicus
2.4.2.12
Alpha-NAD+
weak
Rattus norvegicus
2.4.2.12
NAD+
kinetics
Rattus norvegicus
2.4.2.12
NADH
weak
Rattus norvegicus
2.4.2.12
NADP+
-
Rattus norvegicus
2.4.2.12
NADPH
weak
Rattus norvegicus
2.4.2.12
nicotinamide hypoxanthine dinucleotide
-
Rattus norvegicus
2.4.2.12
nicotinamide mononucleotide
kinetics
Rattus norvegicus
2.4.2.12
nicotinamide mononucleotide-H2
strong, kinetics
Rattus norvegicus
2.4.2.12
nicotinamide riboside
kinetics
Rattus norvegicus
2.4.2.12
nicotinate adenine dinucleotide
weak
Rattus norvegicus
2.4.2.12
Thionicotinamide
weak, kinetics
Rattus norvegicus
2.4.2.12
Thionicotinamide adenine dinucleotide
-
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.4.2.12
0.001
-
nicotinamide
in the presence of ATP
Rattus norvegicus
2.4.2.12
100
-
nicotinamide
in the absence of ATP
Rattus norvegicus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.4.2.12
Mg2+
requirement
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Rattus norvegicus
-
nicotinamide D-ribonucleotide + diphosphate
-
Rattus norvegicus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.12
Rattus norvegicus
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
2.4.2.12
nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
mechanism
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.4.2.12
0.003
-
-
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
489739
Rattus norvegicus
nicotinamide D-ribonucleotide + diphosphate
-
489739
Rattus norvegicus
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
beta-nicotinamide
489739
Rattus norvegicus
nicotinamide D-ribonucleotide + diphosphate
-
489739
Rattus norvegicus
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.4.2.12
37
-
assay at
Rattus norvegicus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.4.2.12
ATP
requirement
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.4.2.12
ATP
requirement
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
3-acetylpyridine
weak, kinetics
Rattus norvegicus
2.4.2.12
3-acetylpyridine adenine dinucleotide
kinetics
Rattus norvegicus
2.4.2.12
5-Fluoronicotinamide
weak, kinetics
Rattus norvegicus
2.4.2.12
6-aminonicotinamide
weak, kinetics
Rattus norvegicus
2.4.2.12
Alpha-NAD+
weak
Rattus norvegicus
2.4.2.12
NAD+
kinetics
Rattus norvegicus
2.4.2.12
NADH
weak
Rattus norvegicus
2.4.2.12
NADP+
-
Rattus norvegicus
2.4.2.12
NADPH
weak
Rattus norvegicus
2.4.2.12
nicotinamide hypoxanthine dinucleotide
-
Rattus norvegicus
2.4.2.12
nicotinamide mononucleotide
kinetics
Rattus norvegicus
2.4.2.12
nicotinamide mononucleotide-H2
strong, kinetics
Rattus norvegicus
2.4.2.12
nicotinamide riboside
kinetics
Rattus norvegicus
2.4.2.12
nicotinate adenine dinucleotide
weak
Rattus norvegicus
2.4.2.12
Thionicotinamide
weak, kinetics
Rattus norvegicus
2.4.2.12
Thionicotinamide adenine dinucleotide
-
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.4.2.12
0.001
-
nicotinamide
in the presence of ATP
Rattus norvegicus
2.4.2.12
100
-
nicotinamide
in the absence of ATP
Rattus norvegicus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.4.2.12
Mg2+
requirement
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Rattus norvegicus
-
nicotinamide D-ribonucleotide + diphosphate
-
Rattus norvegicus
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.4.2.12
0.003
-
-
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
489739
Rattus norvegicus
nicotinamide D-ribonucleotide + diphosphate
-
489739
Rattus norvegicus
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
beta-nicotinamide
489739
Rattus norvegicus
nicotinamide D-ribonucleotide + diphosphate
-
489739
Rattus norvegicus
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.4.2.12
37
-
assay at
Rattus norvegicus