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Literature summary extracted from

  • Dietrich, L.S.; Muniz, O.
    Inhibition of nicotinamide phosphoribosyltransferase by pyridine nucleotides (1972), Biochemistry, 11, 1691-1695.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.12 3-acetylpyridine weak, kinetics Rattus norvegicus
2.4.2.12 3-acetylpyridine adenine dinucleotide kinetics Rattus norvegicus
2.4.2.12 5-Fluoronicotinamide weak, kinetics Rattus norvegicus
2.4.2.12 6-aminonicotinamide weak, kinetics Rattus norvegicus
2.4.2.12 Alpha-NAD+ weak Rattus norvegicus
2.4.2.12 NAD+ kinetics Rattus norvegicus
2.4.2.12 NADH weak Rattus norvegicus
2.4.2.12 NADP+
-
 Rattus norvegicus
2.4.2.12 NADPH weak Rattus norvegicus
2.4.2.12 nicotinamide hypoxanthine dinucleotide
-
 Rattus norvegicus
2.4.2.12 nicotinamide mononucleotide kinetics Rattus norvegicus
2.4.2.12 nicotinamide mononucleotide-H2 strong, kinetics Rattus norvegicus
2.4.2.12 nicotinamide riboside kinetics Rattus norvegicus
2.4.2.12 nicotinate adenine dinucleotide weak Rattus norvegicus
2.4.2.12 Thionicotinamide weak, kinetics Rattus norvegicus
2.4.2.12 Thionicotinamide adenine dinucleotide
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.12 0.001
-
 nicotinamide in the presence of ATP Rattus norvegicus
2.4.2.12 100
-
 nicotinamide in the absence of ATP Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.12 Mg2+ requirement Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Rattus norvegicus
-
 nicotinamide D-ribonucleotide + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.12 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.2.12 nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate mechanism Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.12 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.12 0.003
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Rattus norvegicus nicotinamide D-ribonucleotide + diphosphate
-
 ?
2.4.2.12 nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate beta-nicotinamide Rattus norvegicus nicotinamide D-ribonucleotide + diphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.12 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.4.2.12 ATP requirement Rattus norvegicus