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Literature summary extracted from

  • Montgomery, J.A.
    Purine nucleoside phosphorylase: a target for drug design (1993), Med. Res. Rev., 13, 209-228.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.2.1 medicine since PNP inhibitors block the catabolism of purine nucleosides to hypoxanthine and guanine, precursors of uric acid, they should be useful in the treatment of goat and other hyperuricemic conditions. A number of parasites, including the malaria parasite, lacking the ability to synthesize purine nucleotides de novo, must utilize host purines, formed by PBP, for DNA synthesis. Thus inhibition of PNP could prevent the spread of parasitic infection Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.1 8-aminoguanine
-
 Homo sapiens
2.4.2.1 8-aminoguanosine
-
 Homo sapiens
2.4.2.1 additional information inhibition by 9-cycloaliphatic methyl and 9-saturated heterocyclic methyl-9-deazapurines Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.1 additional information Bos taurus
-
 ?
-
 ?
2.4.2.1 additional information Homo sapiens children lacking PNP activity exhibit severe T cell immunodeficiency while maintaining normal or exaggerated B cell function. The PNP deficiency results in very low uric acid concentrations and high concentrations of the nucleoside substrate of PNP in plasma and urine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.1 Bos taurus
-
-
-
2.4.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.1 erythrocyte
-
 Homo sapiens
-
2.4.2.1 spleen
-
 Homo sapiens
-
2.4.2.1 spleen
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.1 8-aminoguanine + alpha-D-ribose 1-phosphate
-
 Homo sapiens 8-aminoguanosine + phosphate
-
 ?
2.4.2.1 8-aminoguanine + alpha-D-ribose 1-phosphate
-
 Bos taurus 8-aminoguanosine + phosphate
-
 ?
2.4.2.1 adenine + deoxyribose 1-phosphate
-
 Homo sapiens deoxyadenosine + phosphate
-
 r
2.4.2.1 adenine + deoxyribose 1-phosphate
-
 Bos taurus deoxyadenosine + phosphate
-
 r
2.4.2.1 additional information
-
 Bos taurus ?
-
 ?
2.4.2.1 additional information children lacking PNP activity exhibit severe T cell immunodeficiency while maintaining normal or exaggerated B cell function. The PNP deficiency results in very low uric acid concentrations and high concentrations of the nucleoside substrate of PNP in plasma and urine Homo sapiens ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.1 0.0002
-
 8-aminoguanine
-
 Homo sapiens
2.4.2.1 0.017
-
 8-aminoguanosine
-
 Homo sapiens