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Literature summary extracted from

  • Yanagisawa, K.; Taniguchi, N.; Makita, A.
    Purification and properties of GM2 synthase, UDP-N-acetylgalactosamine: GM3 beta-N-acetylgalactosaminyltransferase from rat liver (1987), Biochim. Biophys. Acta, 919, 213-220.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.4.1.92 detergents stabilize Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.92 Chelex-100
-
Rattus norvegicus
2.4.1.92 EDTA
-
Rattus norvegicus
2.4.1.92 UDPgalactose
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.92 0.017
-
UDP-N-acetyl-D-galactosamine
-
Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.92 Ca2+ not Rattus norvegicus
2.4.1.92 Co2+ not Rattus norvegicus
2.4.1.92 Cu2+ activation, can replace Ni2+ to some extent Rattus norvegicus
2.4.1.92 Fe2+
-
Rattus norvegicus
2.4.1.92 Mg2+ not Rattus norvegicus
2.4.1.92 Mn2+ can replace Ni2+ to some extent Rattus norvegicus
2.4.1.92 additional information no activation by Zn2+ Rattus norvegicus
2.4.1.92 Ni2+ requirement, most active, 10-20 mM Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.92 64000
-
2 * 64000, SDS-PAGE Rattus norvegicus
2.4.1.92 120000
-
gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.92 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.92 Triton X-100 solubilized, affinity chromatography on GM3-acid Sepharose Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.92 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.92 0.000149
-
-
Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.4.1.92 -80°C, stable in 20% v/v glycerol, 1% v/v Triton X-100 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.92 additional information no substrate: blood type H glycoprotein, deglucosylated bovine submaxillary mucin, various ceramides Rattus norvegicus ?
-
?
2.4.1.92 UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide 73%-78% as effective as GM3(N-glycolylneuraminic acid) Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM2(N-acetylneuraminic acid)-ganglioside ?
2.4.1.92 UDP-N-acetyl-D-galactosamine + GM3(N-acetylneuraminic acid)-ganglioside
-
Rattus norvegicus UDP + GM2(N-acetylneuraminic acid)-ganglioside
-
?
2.4.1.92 UDP-N-acetyl-D-galactosamine + GM3(N-glycolylneuraminic acid)-ganglioside best substrate Rattus norvegicus UDP + GM2(N-glycolylneuraminic acid)-ganglioside
-
?
2.4.1.92 UDP-N-acetyl-D-galactosamine + N-acetylneuraminelactose i.e. sialyllactose Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-N-acetylneuraminelactose
-
?

Subunits

EC Number Subunits Comment Organism
2.4.1.92 dimer 2 * 64000, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.92 6.7 6.9
-
Rattus norvegicus