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Literature summary extracted from

  • Hashimoto, Y.; Sekine, M.; Iwasaki, K.; Suzuki, A.
    Purification and characterization of UDP-N-acetylgalactosamine GM3/GD3 N-acetylgalactosaminyltransferase from mouse liver (1993), J. Biol. Chem., 268, 25857-25864.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.92 Detergents requirement, solubilized enzyme, e.g. Triton X-100 Mus musculus
2.4.1.92 Endogen lipid factor
-
Mus musculus
2.4.1.92 Triton X-100
-
Mus musculus

General Stability

EC Number General Stability Organism
2.4.1.92 glycerol, 20% v/v, stabilizes Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.92 0.007
-
UDP-N-acetyl-D-galactosamine
-
Mus musculus
2.4.1.92 0.027
-
GD3(N-glycolylneuraminic acid)-ganglioside
-
Mus musculus
2.4.1.92 0.16
-
GM3(N-glycolylneuraminic acid)
-
Mus musculus
2.4.1.92 0.35
-
GD3(N-acetylneuraminic acid)
-
Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.92 Golgi apparatus
-
Mus musculus 5794
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.92 Ca2+ activation, 27% as effective as Mn2+ Mus musculus
2.4.1.92 Co2+ 62% as effective as Mn2+ Mus musculus
2.4.1.92 Fe2+ activation, can replace Ni2+ to some extent, 17% as effective as Mn2+ Mus musculus
2.4.1.92 Mg2+ activation, 22% as effective as Mn2+ Mus musculus
2.4.1.92 Mn2+ requirement, 2.5-10 mM Mus musculus
2.4.1.92 Ni2+ 5% as effective as Mn2+ Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.92 65000
-
2 * 65000, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.92 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.92
-
Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.92 liver
-
Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.92 3.6
-
-
Mus musculus

Storage Stability

EC Number Storage Stability Organism
2.4.1.92 -70°C, 3 months, crude Mus musculus
2.4.1.92 4°C, purified enzyme, at least 6 days in 20% v/v glycerol, 1% w/v heptylthioglucoside, 1 M sucrose, 0.2 M NaCl and 1 mM EDTA in 0.03 M cacodylate buffer, pH 6.9 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.92 additional information no substrate: lactosylceramide, sialylparagloboside, GM1b(N-glycolylneuraminic acid), GD1a(N-acetylneuraminic acid), GT1b(N-acetylneuraminic acid), GQ1b(N-acetylneuraminic acid), GM1a(N-acetylneuraminic acid), GD1b(N-acetylneuraminic acid), globoside Mus musculus ?
-
?
2.4.1.92 additional information poor substrate: sialyllactose Mus musculus ?
-
?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + GD3(N-acetylneuraminic acid)-ganglioside
-
Mus musculus UDP + GD2(N-acetylneuraminic acid)-ganglioside
-
?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + GD3(N-glycolylneuraminic acid)-ganglioside
-
Mus musculus UDP + GD2(N-glycolylneuraminic acid)-ganglioside
-
?
2.4.1.92 UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide 73%-78% as effective as GM3(N-glycolylneuraminic acid) Mus musculus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM2(N-acetylneuraminic acid)-ganglioside ?
2.4.1.92 UDP-N-acetyl-D-galactosamine + GD3-ganglioside GD3(N-glycolylneuraminic acid): 66% as effective as GM3(N-glycolylneuraminic acid), GD3(N-acetylneuraminic acid): 76% as effective as GM3(N-glycolylneuraminic acid) Mus musculus UDP + GD2-ganglioside
-
?
2.4.1.92 UDP-N-acetyl-D-galactosamine + GM3(N-acetylneuraminic acid)-ganglioside
-
Mus musculus UDP + GM2(N-acetylneuraminic acid)-ganglioside
-
?
2.4.1.92 UDP-N-acetyl-D-galactosamine + GM3(N-glycolylneuraminic acid)-ganglioside best substrate Mus musculus UDP + GM2(N-glycolylneuraminic acid)-ganglioside
-
?

Subunits

EC Number Subunits Comment Organism
2.4.1.92 dimer 2 * 65000, SDS-PAGE Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.92 37
-
assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.92 7.5 7.9
-
Mus musculus