Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dicesare, J.L.; Dain, J.A.
    The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain (1971), Biochim. Biophys. Acta, 231, 385-393.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.92 Detergents CF-54, Tween 80 Rattus norvegicus
2.4.1.92 Triton CF-54
-
 Rattus norvegicus
2.4.1.92 Tween 80
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.92 0.0166
-
 GM3
-
 Rattus norvegicus
2.4.1.92 0.057
-
 UDP-N-acetyl-D-galactosamine
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.92 microsome
-
 Rattus norvegicus
-
-
2.4.1.92 mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.92 Ca2+ not Rattus norvegicus
2.4.1.92 Mg2+ not Rattus norvegicus
2.4.1.92 Mn2+
-
 Rattus norvegicus
2.4.1.92 additional information no activation by K+, Al3+ Rattus norvegicus
2.4.1.92 Ni2+ not Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.92 UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide Rattus norvegicus involved in biosynthesis of gangliosides in brain UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.92 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.92 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.92 GM3(O-acetyl-(N-glycolyl)neuraminic acid) + UDP-N-acetyl-D-galactosamine less effective substrate Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-GM3(O-acetyl-(N-glycolyl)neuraminic acid)
-
 ?
2.4.1.92 additional information poor substrate: GM2-, GM1-, GD1b- and GT1-gangliosides and various ceramides Rattus norvegicus ?
-
 ?
2.4.1.92 additional information no substrate: N-acetylglucosamine Rattus norvegicus ?
-
 ?
2.4.1.92 UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide less effective: GM3(O-acetyl-(N-glycolyl)neuraminic acid) Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM2(N-acetylneuraminic acid)-ganglioside ?
2.4.1.92 UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM3(N-acetylneuraminic acid), best substrate Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide i.e. GM2(N-acetylneuraminic acid)-ganglioside ?
2.4.1.92 UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide involved in biosynthesis of gangliosides in brain Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
-
 ?
2.4.1.92 UDP-N-acetyl-D-galactosamine + GM3(N-glycolylneuraminic acid)-ganglioside not as effective as GM3(N-acetylneuraminic acid) Rattus norvegicus UDP + GM2(N-glycolylneuraminic acid)-ganglioside
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.92 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.92 6.8 7.2
-
 Rattus norvegicus