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Literature summary extracted from

  • Ramakrishnan, B.; Shah, P.S.; Qasba, P.K.
    alpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine. Crystal structure of beta4Gal-T1*LA complex with UDP-Glc (2001), J. Biol. Chem., 276, 37665-37671.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.38 alpha-lactalbumin stimulates transfer of glucose from UDPglucose to N-acetylglucosamine Bos taurus
2.4.1.38 alpha-lactalbumin stimulates transfer of galactose from UDPgalactose to N-acetylgalactosamine Bos taurus
2.4.1.90 alpha-lactalbumin stimulates transfer of glucose from UDPglucose to N-acetylglucosamine Bos taurus
2.4.1.90 alpha-lactalbumin stimulates transfer of galactose from UDPgalactose to N-acetylgalactosamine Bos taurus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.38 crystal structure of enzyme-alpha-lactalbumin complex with UDP-Glc Bos taurus
2.4.1.90 crystal structure of enzyme-alpha-lactalbumin complex with UDP-Glc Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.38 Bos taurus
-
-
-
2.4.1.90 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.38 milk
-
 Bos taurus
-
2.4.1.90 milk
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.38 additional information enzyme also catalyzes transfer of glucose from UDPglucose to N-acetylglucosamine Bos taurus ?
-
 ?
2.4.1.38 UDPgalactose + glucose in presence of alpha-lactalbumin Bos taurus lactose + UDP
-
 ?
2.4.1.38 UDPgalactose + N-acetylglucosamine
-
 Bos taurus UDP + N-acetyllactosamine
-
 ?
2.4.1.90 additional information enzyme also catalyzes transfer of glucose from UDPglucose to N-acetylglucosamine Bos taurus ?
-
 ?
2.4.1.90 UDPgalactose + glucose in presence of alpha-lactalbumin Bos taurus lactose + UDP
-
 ?
2.4.1.90 UDPgalactose + N-acetylglucosamine
-
 Bos taurus UDP + N-acetyllactosamine
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.1.38 additional information
-
 additional information turnover number for UDPglucose in absence of alpha-lactalbumin is 3.48 and 14.8 in presence of alpha-lactalbumin Bos taurus
2.4.1.90 additional information
-
 additional information turnover number for UDPglucose in absence of alpha-lactalbumin is 3.48 and 14.8 in presence of alpha-lactalbumin Bos taurus