EC Number | Application | Comment | Organism |
---|---|---|---|
2.4.1.80 | medicine | - |
Homo sapiens |
2.4.1.80 | medicine | enzyme inhibition is a possible target for chemotherapeutic agents for a number of diseases, including cancer | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.80 | cloning from rat brain genetic library and expression in Escherichia coli BL21(DE3) | Rattus norvegicus |
2.4.1.80 | functional expression in Escherichia coli BL21(DE3) | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.80 | EDTA | no inhibition | Rattus norvegicus | |
2.4.1.80 | additional information | - |
Gallus gallus | |
2.4.1.80 | additional information | - |
Homo sapiens | |
2.4.1.80 | additional information | no inhibition by DTT | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.1.80 | Golgi membrane | integral membrane protein | Sus scrofa | 139 | - |
2.4.1.80 | Golgi membrane | orientation to the cytosolic side | Rattus norvegicus | 139 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.80 | Ca2+ | stimulates | Mus musculus | |
2.4.1.80 | Ca2+ | stimulates | Homo sapiens | |
2.4.1.80 | Ca2+ | stimulates | Rattus norvegicus | |
2.4.1.80 | Mg2+ | stimulates | Mus musculus | |
2.4.1.80 | Mg2+ | stimulates | Homo sapiens | |
2.4.1.80 | Mg2+ | stimulates | Rattus norvegicus | |
2.4.1.80 | Mg2+ | stimulates | Sus scrofa | |
2.4.1.80 | Mn2+ | stimulates | Mus musculus | |
2.4.1.80 | Mn2+ | stimulates | Homo sapiens | |
2.4.1.80 | Mn2+ | stimulates | Rattus norvegicus | |
2.4.1.80 | Mn2+ | stimulates | Sus scrofa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.4.1.80 | additional information | - |
- |
Mus musculus |
2.4.1.80 | additional information | - |
- |
Homo sapiens |
2.4.1.80 | additional information | - |
- |
Rattus norvegicus |
2.4.1.80 | additional information | - |
enzyme forms dimeric or oligomeric complexes with another protein in the Golgi membrane vivo, topology | Homo sapiens |
2.4.1.80 | additional information | - |
enzyme forms dimeric or oligomeric complexes with another protein in the Golgi membrane vivo, topology | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.80 | UDP-glucose + N-acylsphingosine | Gallus gallus | - |
UDP + D-glucosyl-N-acylsphingosine | - |
? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | Homo sapiens | - |
UDP + D-glucosyl-N-acylsphingosine | - |
? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | Sus scrofa | - |
UDP + D-glucosyl-N-acylsphingosine | - |
? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | Mus musculus | - |
UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | Rattus norvegicus | - |
UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | Homo sapiens | - |
UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | Rattus norvegicus Sprague-Dawley | - |
UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.80 | Gallus gallus | - |
- |
- |
2.4.1.80 | Homo sapiens | - |
- |
- |
2.4.1.80 | Homo sapiens | Q16739 | - |
- |
2.4.1.80 | Mus musculus | - |
- |
- |
2.4.1.80 | Rattus norvegicus | - |
Sprague-Dawley | - |
2.4.1.80 | Rattus norvegicus | Q9R0E0 | - |
- |
2.4.1.80 | Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
2.4.1.80 | Sus scrofa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.1.80 | partial from Golgi membranes | Rattus norvegicus |
2.4.1.80 | solubilization method | Rattus norvegicus |
2.4.1.80 | solubilization method | Sus scrofa |
EC Number | Renatured (Comment) | Organism |
---|---|---|
2.4.1.80 | reconstitution of solubilized enzyme in detergent-free lipid vesicles | Rattus norvegicus |
2.4.1.80 | reconstitution of solubilized enzyme in detergent-free lipid vesicles | Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.80 | keratinocyte | - |
Homo sapiens | - |
2.4.1.80 | liver | - |
Mus musculus | - |
2.4.1.80 | liver | - |
Homo sapiens | - |
2.4.1.80 | liver | low level | Rattus norvegicus | - |
2.4.1.80 | lung | - |
Rattus norvegicus | - |
2.4.1.80 | lung | - |
Homo sapiens | - |
2.4.1.80 | spleen | - |
Rattus norvegicus | - |
2.4.1.80 | testis | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.4.1.80 | additional information | - |
- |
Gallus gallus |
2.4.1.80 | additional information | - |
- |
Mus musculus |
2.4.1.80 | additional information | - |
- |
Homo sapiens |
2.4.1.80 | additional information | - |
- |
Sus scrofa |
2.4.1.80 | additional information | - |
fluorescence assay method | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.80 | UDP-glucose + N-acylsphingosine | - |
Gallus gallus | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | - |
Homo sapiens | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | - |
Sus scrofa | UDP + D-glucosyl-N-acylsphingosine | - |
? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | - |
Mus musculus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | - |
Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | - |
Homo sapiens | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | i.e. ceramide | Gallus gallus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | i.e. ceramide | Mus musculus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | i.e. ceramide | Homo sapiens | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | i.e. ceramide | Rattus norvegicus | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | i.e. ceramide | Sus scrofa | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | - |
Rattus norvegicus Sprague-Dawley | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-acylsphingosine | i.e. ceramide | Rattus norvegicus Sprague-Dawley | UDP + D-glucosyl-N-acylsphingosine | i.e. glucosylceramide | ? | |
2.4.1.80 | UDP-glucose + N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine | synthetic fluorescent ceramide substrate analogue for fluorescence enzyme assay | Rattus norvegicus | UDP + D-glucosyl-N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine | - |
? | |
2.4.1.80 | UDP-glucose + N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine | synthetic fluorescent ceramide substrate analogue for fluorescence enzyme assay | Rattus norvegicus Sprague-Dawley | UDP + D-glucosyl-N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.80 | GCS | - |
Mus musculus |
2.4.1.80 | GCS | - |
Homo sapiens |
2.4.1.80 | GCS | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.4.1.80 | 37 | - |
assay at | Mus musculus |
2.4.1.80 | 37 | - |
assay at | Rattus norvegicus |
2.4.1.80 | 37 | - |
assay at | Sus scrofa |
2.4.1.80 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.4.1.80 | 7.4 | - |
- |
Mus musculus |
2.4.1.80 | 7.4 | - |
- |
Homo sapiens |
2.4.1.80 | 7.4 | - |
assay at | Rattus norvegicus |