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Literature summary extracted from

  • Miyoshi, E.; Noda, K.; Yamaguchi, Y.; Inoue, S.; Ikeda, Y.; Wang, W.; Ko, J.H.; Uozumi, N.; Li, W.; Taniguchi, N.
    The alpha1-6-fucosyltransferase gene and its biological significance (1999), Biochim. Biophys. Acta, 1473, 9-20.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.68 medicine serum alpha1-6-fucosylated alpha-fetoprotein is employed for an early diagnosis of patients with hepatoma and hepatic disease Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.68
-
Sus scrofa
2.4.1.68
-
Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.68 additional information gene transfection to human hepatoma and mice mutants, overexpression and effects on tumour growth Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.68 Cd2+
-
Homo sapiens
2.4.1.68 Co2+
-
Homo sapiens
2.4.1.68 Cu2+
-
Homo sapiens
2.4.1.68 Cu2+
-
Sus scrofa
2.4.1.68 additional information
-
Homo sapiens
2.4.1.68 additional information
-
Sus scrofa
2.4.1.68 Ni2+
-
Homo sapiens
2.4.1.68 Ni2+
-
Sus scrofa
2.4.1.68 Zn2+
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.68 0.0042
-
GDP-L-fucose
-
Homo sapiens
2.4.1.68 0.025
-
N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine)
-
Sus scrofa
2.4.1.68 0.028
-
GDP-L-fucose
-
Homo sapiens
2.4.1.68 0.029
-
asialo-agalacto-transferrin-glycopeptide
-
Homo sapiens
2.4.1.68 0.046
-
GDP-L-fucose
-
Sus scrofa
2.4.1.68 0.066
-
asialo-agalacto-transferrin-glycopeptide
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.68 additional information
-
Homo sapiens
-
-
2.4.1.68 additional information no mRNA expression in pancreas and liver Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.68 Ca2+ activation Homo sapiens
2.4.1.68 Mg2+ activation Homo sapiens
2.4.1.68 Mg2+ fibroblast, required Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.68 additional information
-
amino acid sequence, alignment and comparison Sus scrofa
2.4.1.68 additional information
-
amino acid sequence, alignment and comparison Homo sapiens
2.4.1.68 additional information
-
amino acid sequence alignment and comparison of conserved regions, consensus peptide motif Homo sapiens
2.4.1.68 additional information
-
amino acid sequence alignment and comparison of conserved regions, consensus peptide motif Sus scrofa
2.4.1.68 34000
-
x * 34000 + x * 39000 Homo sapiens
2.4.1.68 39000
-
x * 34000 + x * 39000 Homo sapiens
2.4.1.68 58000
-
1 * 58000, SDS-PAGE Homo sapiens
2.4.1.68 58000
-
x * 58000, SDS-PAGE Sus scrofa
2.4.1.68 60000
-
x * 60000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.68 Homo sapiens
-
-
-
2.4.1.68 Homo sapiens Q9BYC5
-
-
2.4.1.68 Rattus norvegicus
-
-
-
2.4.1.68 Sus scrofa
-
-
-
2.4.1.68 Sus scrofa P79282
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.68 no glycoprotein no N-glycosylation sites in predicted amino acid sequence Sus scrofa
2.4.1.68 no glycoprotein no N-glycosylation sites in predicted amino acid sequence Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.68
-
Homo sapiens
2.4.1.68
-
Sus scrofa

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.1.68 GDP-beta-L-fucose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = GDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein] type II transmembrane protein Homo sapiens
2.4.1.68 GDP-beta-L-fucose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = GDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein] type II transmembrane protein Sus scrofa
2.4.1.68 GDP-beta-L-fucose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] = GDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein] fucosyltransferase gene superfamily Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.68 blood platelet thrombin-activated neutrophils release cathepsin G and elastase during coagulation of blood, which promotes the degranulation of platelets and hence the secretion of alpha-6-fucosyltransferase Homo sapiens
-
2.4.1.68 brain
-
Rattus norvegicus
-
2.4.1.68 brain
-
Sus scrofa
-
2.4.1.68 hepatoma cell expression in hepatoma tissues and their surrounding tissues and in tissues with chronic disease, overview Homo sapiens
-
2.4.1.68 hepatoma cell expression in hepatoma tissues and their surrounding tissues and in tissues with chronic disease, overview Rattus norvegicus
-
2.4.1.68 intestine
-
Rattus norvegicus
-
2.4.1.68 liver
-
Rattus norvegicus
-
2.4.1.68 liver
-
Sus scrofa
-
2.4.1.68 liver enzyme is expressed in hepatoma tissues and their surrounding tissues with chronic disease, but not in normal liver Homo sapiens
-
2.4.1.68 lung cancer cell line
-
Homo sapiens
-
2.4.1.68 MKN-45 cell
-
Homo sapiens
-
2.4.1.68 serum
-
Homo sapiens
-
2.4.1.68 serum
-
Rattus norvegicus
-
2.4.1.68 skin fibroblast
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.68 additional information
-
-
Rattus norvegicus
2.4.1.68 additional information
-
-
Sus scrofa
2.4.1.68 additional information
-
activity in hepatic disease Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.68 GDP-L-fucose + asialo-agalactotransferrin glycopeptide biantennary to tetraantennary substrates, with the triantennary substrate showing the highest activity Homo sapiens GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of the asialo-agalactotransferrin glycopeptide
-
?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
Homo sapiens GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
Rattus norvegicus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
Sus scrofa GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine)
-
Sus scrofa GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine)
-
?

Subunits

EC Number Subunits Comment Organism
2.4.1.68 ? x * 60000, SDS-PAGE Homo sapiens
2.4.1.68 ? x * 58000, SDS-PAGE Sus scrofa
2.4.1.68 ? x * 34000 + x * 39000 Homo sapiens
2.4.1.68 monomer 1 * 58000, SDS-PAGE Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.68 30 37
-
Sus scrofa
2.4.1.68 30 37
-
Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.4.1.68 4 10
-
Sus scrofa
2.4.1.68 4 10
-
Homo sapiens