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Literature summary extracted from

  • Struppe, E.; Staudacher, E.
    Occurrence of GDP-L-fucose:beta-N-acetylglucosamine (Fuc to Asn-linked GlcNAc) alpha1,6-fucosyltransferases in porcine, sheep, bovine, rabbit and chicken tissues (2000), Biochim. Biophys. Acta, 1475, 360-368.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.68 Ca2+
-
 Ovis aries
2.4.1.68 Co2+
-
 Ovis aries
2.4.1.68 Cu2+ complete inhibition Bos taurus
2.4.1.68 Cu2+ complete inhibition Oryctolagus cuniculus
2.4.1.68 Cu2+ complete inhibition Ovis aries
2.4.1.68 Cu2+
-
 Sus scrofa
2.4.1.68 EDTA slight inhibition Bos taurus
2.4.1.68 Mg2+ slight inhibition Ovis aries
2.4.1.68 Mn2+ slight inhibition Ovis aries
2.4.1.68 Mn2+ slight inhibition Sus scrofa
2.4.1.68 additional information no effect of Ca2+, Co2+ Bos taurus
2.4.1.68 additional information no effect of EDTA, Ni2+ Oryctolagus cuniculus
2.4.1.68 additional information no effect of EDTA, Ba2+ Ovis aries
2.4.1.68 additional information
-
 Sus scrofa
2.4.1.68 N-ethylmaleimide slight inhibition Gallus gallus
2.4.1.68 N-ethylmaleimide slight inhibition Oryctolagus cuniculus
2.4.1.68 N-ethylmaleimide not affected by Ovis aries
2.4.1.68 N-ethylmaleimide not affected by Sus scrofa
2.4.1.68 Ni2+
-
 Bos taurus
2.4.1.68 Ni2+
-
 Ovis aries
2.4.1.68 Ni2+
-
 Sus scrofa
2.4.1.68 Zn2+ strong inhibition Bos taurus
2.4.1.68 Zn2+ strong inhibition Oryctolagus cuniculus
2.4.1.68 Zn2+ strong inhibition Ovis aries

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.68 Ba2+ slight activation Bos taurus
2.4.1.68 Ba2+ activation Oryctolagus cuniculus
2.4.1.68 Ca2+ activation Bos taurus
2.4.1.68 Ca2+ activation Oryctolagus cuniculus
2.4.1.68 Co2+ activation Oryctolagus cuniculus
2.4.1.68 Mg2+ slight activation Bos taurus
2.4.1.68 Mg2+ slight activation Oryctolagus cuniculus
2.4.1.68 Mn2+ activation Bos taurus
2.4.1.68 Mn2+ activation Oryctolagus cuniculus
2.4.1.68 additional information no effect of Ca2+, Co2+ Bos taurus
2.4.1.68 additional information effect of divalent metal ions is tissue-dependent Bos taurus
2.4.1.68 additional information effect of divalent metal ions is tissue-dependent Oryctolagus cuniculus
2.4.1.68 additional information effect of divalent metal ions is tissue-dependent Ovis aries
2.4.1.68 additional information no effect of EDTA, Ba2+ Ovis aries
2.4.1.68 additional information no effect of EDTA, Ni2+ Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine Gallus gallus i.e. GnGn-peptide GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine Sus scrofa i.e. GnGn-peptide GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine Bos taurus i.e. GnGn-peptide GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine Oryctolagus cuniculus i.e. GnGn-peptide GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine Ovis aries i.e. GnGn-peptide GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
2.4.1.68 acetonitrile 10%, stable Gallus gallus
2.4.1.68 acetonitrile 10%, stable Sus scrofa
2.4.1.68 acetonitrile 10%, stable Bos taurus
2.4.1.68 acetonitrile 10%, stable Oryctolagus cuniculus
2.4.1.68 acetonitrile 10%, stable Ovis aries
2.4.1.68 Methanol 10%, stable Gallus gallus
2.4.1.68 Methanol 10%, stable Sus scrofa
2.4.1.68 Methanol 10%, stable Bos taurus
2.4.1.68 Methanol 10%, stable Oryctolagus cuniculus
2.4.1.68 Methanol 10%, stable Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.68 Bos taurus
-
-
-
2.4.1.68 Gallus gallus
-
-
-
2.4.1.68 Oryctolagus cuniculus
-
-
-
2.4.1.68 Ovis aries
-
-
-
2.4.1.68 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.68 partially from several organs Gallus gallus
2.4.1.68 partially from several organs Sus scrofa
2.4.1.68 partially from several organs Bos taurus
2.4.1.68 partially from several organs Oryctolagus cuniculus
2.4.1.68 partially from several organs Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.68 brain
-
 Gallus gallus
-
2.4.1.68 brain
-
 Sus scrofa
-
2.4.1.68 brain
-
 Bos taurus
-
2.4.1.68 brain
-
 Oryctolagus cuniculus
-
2.4.1.68 brain
-
 Ovis aries
-
2.4.1.68 commercial preparation kidney Bos taurus
-
2.4.1.68 heart
-
 Gallus gallus
-
2.4.1.68 heart
-
 Sus scrofa
-
2.4.1.68 heart
-
 Bos taurus
-
2.4.1.68 heart
-
 Oryctolagus cuniculus
-
2.4.1.68 heart
-
 Ovis aries
-
2.4.1.68 liver
-
 Gallus gallus
-
2.4.1.68 liver
-
 Sus scrofa
-
2.4.1.68 liver
-
 Bos taurus
-
2.4.1.68 liver
-
 Oryctolagus cuniculus
-
2.4.1.68 liver
-
 Ovis aries
-
2.4.1.68 lung
-
 Gallus gallus
-
2.4.1.68 lung
-
 Sus scrofa
-
2.4.1.68 lung
-
 Bos taurus
-
2.4.1.68 lung
-
 Oryctolagus cuniculus
-
2.4.1.68 lung
-
 Ovis aries
-

Storage Stability

EC Number Storage Stability Organism
2.4.1.68 -20°C to 37°C: 24 h, no loss of activity Gallus gallus
2.4.1.68 -20°C to 37°C: 24 h, no loss of activity Sus scrofa
2.4.1.68 -20°C to 37°C: 24 h, no loss of activity Bos taurus
2.4.1.68 -20°C to 37°C: 24 h, no loss of activity Oryctolagus cuniculus
2.4.1.68 -20°C to 37°C: 24 h, no loss of activity Ovis aries

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine i.e. GnGn-peptide Gallus gallus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine i.e. GnGn-peptide Sus scrofa GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine i.e. GnGn-peptide Bos taurus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine i.e. GnGn-peptide Oryctolagus cuniculus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine i.e. GnGn-peptide Ovis aries GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine i.e. GnGn-peptide Gallus gallus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine i.e. GnGn-peptide Sus scrofa GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine i.e. GnGn-peptide Bos taurus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine i.e. GnGn-peptide Oryctolagus cuniculus GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine i.e. GnGn-peptide Ovis aries GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.68 additional information
-
 overview: tissue specific pH-optima Gallus gallus
2.4.1.68 additional information
-
 overview: tissue specific pH-optima Sus scrofa
2.4.1.68 additional information
-
 overview: tissue specific pH-optima Bos taurus
2.4.1.68 additional information
-
 overview: tissue specific pH-optima Oryctolagus cuniculus
2.4.1.68 additional information
-
 overview: tissue specific pH-optima Ovis aries

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.4.1.68 4 9
-
 Gallus gallus
2.4.1.68 4 9
-
 Sus scrofa
2.4.1.68 4 9
-
 Bos taurus
2.4.1.68 4 9
-
 Oryctolagus cuniculus
2.4.1.68 4 9
-
 Ovis aries