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Literature summary extracted from

  • Shao, M.C.; Sokolik, C.W.; Wold, F.
    Specificity studies of the GDP-[L]-fucose:2-acetamido-2-deoxy-beta-[D]-glucoside (Fuc-Asn-linked GlcNAc) 6-alpha-[L]-fucosyltransferase from rat-liver Golgi membranes (1994), Carbohydr. Res., 251, 163-173.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.68 streptavidin inhibition due to stereochemical blockage of the fucosylation site Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.68 Golgi membrane
-
 Rattus norvegicus 139
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.68 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.68 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.68 GDP-beta-fucose + (N-acetylglucosaminyl)2-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine
-
 Rattus norvegicus GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of (N-acetylglucosaminyl)2-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine
-
 ?
2.4.1.68 GDP-beta-fucose + Gal-N-acetylglucosaminyl-Man5-GlcNAc2-(6-biotinamidohexanoyl)asparagine low activity Rattus norvegicus GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of Gal-N-acetylglucosaminyl-Man5-GlcNAc2-(6-biotinamidohexanoyl)asparagine
-
 ?
2.4.1.68 GDP-beta-fucose + Gal2-(N-acetylglucosaminyl)2-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine low activity Rattus norvegicus GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of Gal2-(N-acetylglucosaminyl)2-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine
-
 ?
2.4.1.68 GDP-beta-fucose + N-acetylglucosaminyl-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine best substrate Rattus norvegicus GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of N-acetylglucosaminyl-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine
-
 ?
2.4.1.68 GDP-beta-fucose + N-acetylglucosaminyl-Man5-GlcNAc2-(6-biotinamidohexanoyl)asparagine
-
 Rattus norvegicus GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of N-acetylglucosaminyl-Man5-GlcNAc2-(6-biotinamidohexanoyl)asparagine
-
 ?
2.4.1.68 additional information substrate specificity Rattus norvegicus ?
-
 ?
2.4.1.68 additional information no activity with Man5-GlcNAc2-(6-biotinamidohexanoyl)asparagine, Sia-Gal2-GlcNAc2-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine and Sia2-Gal2-GlcNAc2-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.68 alpha1,6-fucosyltransferase
-
 Rattus norvegicus
2.4.1.68 GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside 6-alpha-L-fucosyltransferase Fuc-Asn-linked N-acetylglucosamine Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.68 6.7
-
 assay at Rattus norvegicus