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Literature summary extracted from

  • Yip, M.C.M.; Dain, J.A.
    Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceramide galactosyltransferase (1970), Biochem. J., 118, 247-252.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.62 Gangliosides and ganglioside components most active: disialoganglioside Lithobates pipiens
2.4.1.62 GM2 above 1.83 mM Lithobates pipiens
2.4.1.62 additional information no inhibition by fetuin, glucosylceramide, lactosylceramide or trihexosylceramide Lithobates pipiens
2.4.1.62 N-acetylneuraminic acid with or without tetrahexosylceramide Lithobates pipiens
2.4.1.62 N-acetylneuraminyllactose weak Lithobates pipiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.62 0.18
-
 N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine
-
 Lithobates pipiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.62 microsome
-
 Lithobates pipiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.62 Mn2+ requirement, Km-value: 2.2 mM Lithobates pipiens
2.4.1.62 additional information no activation Co2+, Na+, Li+ Lithobates pipiens
2.4.1.62 additional information no activation by K+, Al3+ Lithobates pipiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.62 Lithobates pipiens
-
 frog
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.62 brain
-
 Lithobates pipiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.62 UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine best acceptor Lithobates pipiens UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.62 7.2 7.3 adult frog brain Lithobates pipiens