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Literature summary extracted from

  • Tencomnao, T.; Yu, R.K.; Kapitonov, D.
    Characterization of the human UDP-galactose:ceramide galactosyltransferase gene promoter (2001), Biochim. Biophys. Acta, 1517, 416-423.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.47 transcriptional regulation of the CGT gene, 2.3 kb CGT promoter Homo sapiens
2.4.1.62 cloning from human cDNA library, promotor identification via primer extension analysis, deletion and cloning of several 5'-end constructs, transient expression in human cell lines derived from oligodendroglioma and neuroblastoma LAN-5, promotor activity is cell type-specific, identification of regulatory elements Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.47 UDPgalactose + 2-(2-hydroxyacyl)sphingosine Homo sapiens key enzyme in the biosynthesis of galactocerebroside, the most abundant glycosphingolipid in the myelin sheath 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP galactocerebroside ?
2.4.1.62 UDPgalactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine Homo sapiens key enzyme in the biosynthesis of the oligodendrocyte- and myelin-specific cerebrosides UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.47 Homo sapiens
-
-
-
2.4.1.62 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.47 glioma cell N-370 FG cells Homo sapiens
-
2.4.1.47 LAN5 cell neuroblastoma cell line Homo sapiens
-
2.4.1.47 oligodendroglioma cell HOG cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.47 UDPgalactose + 2-(2-hydroxyacyl)sphingosine
-
 Homo sapiens 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP
-
 ?
2.4.1.47 UDPgalactose + 2-(2-hydroxyacyl)sphingosine key enzyme in the biosynthesis of galactocerebroside, the most abundant glycosphingolipid in the myelin sheath Homo sapiens 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP galactocerebroside ?
2.4.1.62 UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine
-
 Homo sapiens UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
-
 ?
2.4.1.62 UDPgalactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine key enzyme in the biosynthesis of the oligodendrocyte- and myelin-specific cerebrosides Homo sapiens UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.62 CGT
-
 Homo sapiens
2.4.1.62 UDP-galactose:ceramide galactosyltransferase
-
 Homo sapiens