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Literature summary extracted from

  • Bosio, A.; Binczek, E.; Le Beau, M.M.; Fernald, A.A.; Stoffel, W.
    The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): Cloning, characterization, and assignment to human chromosome 4, band q26 (1996), Genomics, 34, 69-75.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.47 cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocyte of CNS and in Schwann cells of PNS Homo sapiens
2.4.1.47 cloning and characterization of the CGT gene, chromosomal localization as a single-copy gene to 4q26 Homo sapiens
2.4.1.47 nucleotide sequence of the cDNA, single-copy gene Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.47 endoplasmic reticulum membrane integrated into ER membrane, enzymatically active part of CGT may be oriented toward the lumen of the ER Homo sapiens 5789
-
2.4.1.47 membrane with transmembrane helical domain, hydrophobic sequence of 20 amino acids in the C-terminal domain Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.47 UDPgalactose + 2-(2-hydroxyacyl)sphingosine Homo sapiens key enzymatic step in the biosynthesis of the galactocerebrosides, cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocytes of CNS and in Schwann cells of PNS 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP galactocerebroside ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.47 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.47 glycoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.47 UDPgalactose + 2-(2-hydroxyacyl)sphingosine
-
 Homo sapiens 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP galactoceramide ?
2.4.1.47 UDPgalactose + 2-(2-hydroxyacyl)sphingosine key enzymatic step in the biosynthesis of the galactocerebrosides, cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocytes of CNS and in Schwann cells of PNS Homo sapiens 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP galactocerebroside ?