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Literature summary extracted from

  • Bennett, E.P.; Hassan, H.; Hollingsworth, M.A.; Clausen, H.
    A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates (1999), FEBS Lett., 460, 226-230.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.41 additional information GalNAc-T7: selectively activated by partial GalNAc glycosylation of peptide substrates derived from the tandem repeats of human Muc2 and rat submaxillary gland mucin Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.41 GalNAc-T7 is cloned and expressed in insect Sf9 cells, open reading frame of 1974 bp, GALNT7 gene encoding GalNAc-T7 is localized on chromosome 4q31.1 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.41 membrane GalNAc-T7: type II transmembrane protein with a hydrophobic signal anchor sequence in residues 10-24 Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide Homo sapiens GalNAc-T7: functions as a follow-up enzyme in the initiation step of O-glycosylation UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide Homo sapiens initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.41 Homo sapiens Q86SF2 GalNAc-T7
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.41 additional information GalNAc-T7: no activity with non-glycosylated peptides and GalNAc-glycosylated Muc1 substrate Homo sapiens ?
-
 ?
2.4.1.41 additional information multiple enzyme isoforms Homo sapiens ?
-
 ?
2.4.1.41 additional information amino acid sequences of seven GalNAc-transferases Homo sapiens ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide GalNAc-T7: exclusive specificity for partially GalNAc-glycosylated acceptor substrates, GalNAc-glycosylated peptide substrates derived from the tandem repeats of human Muc2 and rat submandibular gland mucin, specificity of GalNAc-T4 Homo sapiens UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide
-
 Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide GalNAc-T7: functions as a follow-up enzyme in the initiation step of O-glycosylation Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?