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Literature summary extracted from

  • Soerensen, T.; White, T.; Wandall, H.H.; Kristensen, A.K.; Roepstorff, P.; Clausen, H.
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. Identification and separation of two distinct transferase activities (1995), J. Biol. Chem., 270, 24166-24173.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.41 HIV-V3 competitive inhibition of Muc2 glycosylation Homo sapiens
2.4.1.41 Muc2 competitive inhibition of HIV-V3 peptide glycosylation Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.41 additional information
-
additional information
-
Rattus norvegicus
2.4.1.41 additional information
-
additional information
-
Sus scrofa
2.4.1.41 additional information
-
additional information values for different human mucin Muc1 peptides Homo sapiens
2.4.1.41 0.23
-
human mucin Muc2 peptide
-
Homo sapiens
2.4.1.41 0.5
-
HIV-V3 peptide
-
Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.41 100000
-
gel filtration Sus scrofa
2.4.1.41 100000
-
gel filtration Ovis sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide Sus scrofa
-
UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide Homo sapiens different enzyme activities are involved in the initiation of GalNAc O-glycosylation and these are differentially expressed in cells and organs UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide Rattus norvegicus different enzyme activities are involved in the initiation of GalNAc O-glycosylation and these are differentially expressed in cells and organs UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.41 Homo sapiens
-
-
-
2.4.1.41 Ovis sp.
-
-
-
2.4.1.41 Rattus norvegicus
-
male rats
-
2.4.1.41 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.41 placenta enzyme, Muc2 peptide affinity chromatography separates two distinct transferase activities with overlapping specificity concerning Muc2 substrate, but which are distinguishable with respect to HIV-V3 substrate Homo sapiens
2.4.1.41 submaxillary gland enzyme, 123.5fold Ovis sp.
2.4.1.41 submaxillary gland enzyme, 25.4fold Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.41 heart ventricle
-
Rattus norvegicus
-
2.4.1.41 kidney
-
Homo sapiens
-
2.4.1.41 kidney expresses GalNAc-T2 Rattus norvegicus
-
2.4.1.41 liver expresses significantly more GalNAc-T2 than GalNAc-T1 Homo sapiens
-
2.4.1.41 additional information quantitative and qualitative differences in different organs Homo sapiens
-
2.4.1.41 additional information quantitative and qualitative differences in different organs Rattus norvegicus
-
2.4.1.41 placenta
-
Homo sapiens
-
2.4.1.41 salivary gland
-
Rattus norvegicus
-
2.4.1.41 salivary gland
-
Sus scrofa
-
2.4.1.41 salivary gland
-
Ovis sp.
-
2.4.1.41 submaxillary gland
-
Sus scrofa
-
2.4.1.41 submaxillary gland
-
Ovis sp.
-
2.4.1.41 testis
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.41 0.09
-
-
Sus scrofa
2.4.1.41 0.11
-
-
Ovis sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.41 additional information different substrate specificities before and after Muc2 affinity chromatography of enzyme Homo sapiens ?
-
?
2.4.1.41 additional information different substrate specificities before and after Muc2 affinity chromatography of enzyme Sus scrofa ?
-
?
2.4.1.41 additional information different substrate specificities before and after Muc2 affinity chromatography of enzyme Ovis sp. ?
-
?
2.4.1.41 additional information existence of multiple enzyme activities, differentially expressed in different organs, at least 2 distinct enzyme specificities Homo sapiens ?
-
?
2.4.1.41 additional information existence of multiple enzyme activities, differentially expressed in different organs, at least 2 distinct enzyme specificities Rattus norvegicus ?
-
?
2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + human mucin Muc2 peptide
-
Homo sapiens ?
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + HIV-V3 peptide submaxillary gland enzyme, low activity Sus scrofa UDP + N-acetyl-D-galactosaminyl-HIV-V3 peptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + HIV-V3 peptide submaxillary gland enzyme, low activity Ovis sp. UDP + N-acetyl-D-galactosaminyl-HIV-V3 peptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + HIV-V3 peptide placenta, but not liver enzyme Homo sapiens UDP + N-acetyl-D-galactosaminyl-HIV-V3 peptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide placenta enzyme Homo sapiens UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide only Ser acceptor sites, with a very low activity Homo sapiens UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide only Ser acceptor sites, with a very low activity Sus scrofa UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide only Ser acceptor sites, with a very low activity Ovis sp. UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide submaxillary gland enzyme Sus scrofa UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin-beta peptide submaxillary gland enzyme Ovis sp. UDP + N-acetyl-D-galactosaminyl-human chorionic gonadotropin-beta peptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide
-
Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptor: SIV3 peptide Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide transfer of GalNAc to a serine or threonine residue on the acceptor protein Ovis sp. UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: human mucin Muc1 and Muc2 peptides, human chorionic gonadotropin-beta peptide, HIV-V3 peptides Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: human mucin Muc1 and Muc2 peptides, human chorionic gonadotropin-beta peptide, HIV-V3 peptides Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: human mucin Muc1 and Muc2 peptides, human chorionic gonadotropin-beta peptide, HIV-V3 peptides Ovis sp. UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide different enzyme activities are involved in the initiation of GalNAc O-glycosylation and these are differentially expressed in cells and organs Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide different enzyme activities are involved in the initiation of GalNAc O-glycosylation and these are differentially expressed in cells and organs Rattus norvegicus UDP + N-acetyl-D-galactosaminyl-polypeptide
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.41 37
-
assay at Homo sapiens
2.4.1.41 37
-
assay at Rattus norvegicus
2.4.1.41 37
-
assay at Sus scrofa