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Literature summary extracted from

  • Cottrell, J.M.; Hall, R.L.; Sturton, R.G.; Kent, P.W.
    Polypeptide N-acetylgalactosaminyltransferase activity in tracheal epithelial microsomes (1992), Biochem. J., 283, 299-305.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.41 Triton X-100 required for maximal activity Sus scrofa
2.4.1.41 Triton X-100 0.1% w/v Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.41 EDTA Na2EDTA, 7.5 mM, complete inhibition Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.41 0.11
-
 UDP-GalNAc
-
 Sus scrofa
2.4.1.41 3
-
 Val-Thr-Pro-Arg-Thr-Pro-Pro-Pro
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.41 membrane membrane-bound Sus scrofa 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.41 Mn2+ requirement Sus scrofa
2.4.1.41 Mn2+ maximal activity at 10 mM Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide Sus scrofa key role in overall control of O-glycosylation UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide Sus scrofa primary step in the production of mucin-type O-linked oligosaccharide groups in glycoproteins UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.41 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.41 tracheal epithelium
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + Val-Thr-Pro-Arg-Thr-Pro-Pro-Pro
-
 Sus scrofa ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + apomucin deglycosylated bovine submaxillary mucin Sus scrofa UDP + N-acetyl-D-galactosaminyl-apomucin
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + myelin basic protein
-
 Sus scrofa UDP + N-acetyl-D-galactosaminyl-myelin basic protein
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide L-threonine specifically O-glycosylated in alpha-configuration, Thr-Pro-Pro-Pro-sequence requires a peptide length of five or more for significant acceptor activity Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide acceptors: bovine submaxillary mucin core protein, myelin basic protein Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide O-glycosylating enzyme, acceptors: synthetic peptides in which the Thr-Pro-Pro-Pro sequence is varied Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide key role in overall control of O-glycosylation Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide primary step in the production of mucin-type O-linked oligosaccharide groups in glycoproteins Sus scrofa UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.41 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.41 7.5
-
-
 Sus scrofa