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Literature summary extracted from

  • Seto, N.O.; Compston, C.A.; Evans, S.V.; Bundle, D.R.; Narang, S.A.; Palcic, M.M.
    Donor substrate specificity of recombinant human blood group A, B and hybrid A/B glycosyltransferases expressed in Escherichia coli (1999), Eur. J. Biochem., 259, 770-775.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.37 expressed in Escherichia coli Homo sapiens
2.4.1.40 expressed in Escherichia coli Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.40 0.013
-
 L-fucosyl-alpha-1,2-beta-galactosyl-O(CH2)7CH3
-
 Homo sapiens
2.4.1.40 0.015
-
 UDP-GalNAc
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.37 Homo sapiens
-
 only four amino acids are responsible for B and A blood group enzymes R176G, G235S, L266M and G268A, the latter two amino acids are responsible for the difference in donor specificity and the first two have roles in acceptor binding and turnover
-
2.4.1.40 Homo sapiens
-
 only four amino acids are responsible for B and A blood group enzymes R176G, G235S, L266M and G268A, the latter two amino acids are responsible for the difference in donor specificity and the first two have roles in acceptor binding and turnover
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.37 UDP-glucose + L-fucosyl-alpha-1,2-beta-galactosyl-O(CH2)7CH3
-
 Homo sapiens UDP + alpha-D-glucosyl-1,3-[alpha-L-fucosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3
-
 ?
2.4.1.40 UDP-Gal + L-fucosyl-alpha-1,2-beta-galactosyl-O(CH2)7CH3
-
 Homo sapiens ?
-
 ?
2.4.1.40 UDP-N-acetyl-D-galactosamine + 2'-fucosyllactose
-
 Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-2'-fucosyllactose
-
 ?
2.4.1.40 UDP-N-acetyl-D-galactosamine + L-fucosyl-alpha-1,2-beta-galactosyl-O(CH2)7CH3
-
 Homo sapiens UDP + alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1,2]-beta-D-galactosyl-O(CH2)7CH3
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.1.37 0.005
-
 UDP-N-acetylgalactosamine
-
 Homo sapiens
2.4.1.37 0.108
-
 UDP-galactose
-
 Homo sapiens
2.4.1.40 0.000333
-
 UDP-Gal
-
 Homo sapiens
2.4.1.40 0.0817
-
 UDP-GalNAc
-
 Homo sapiens