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Literature summary extracted from

  • Wood, R.L.; Miller, T.K.; Wright, A.; McCarthy, P.; Taft, C.S.; Pomponi, S.; Selitrennikoff, C.P.
    Characterization and optimization of in vitro assay conditions for (1,3)beta-glucan synthase activity from Aspergillus fumigatus and Candida albicans for enzyme inhibition screening (1998), J. Antibiot., 51, 665-675.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.34 cilofungin
-
 Aspergillus fumigatus
2.4.1.34 cilofungin
-
 Candida albicans
2.4.1.34 cilofungin
-
 Neurospora crassa
2.4.1.34 MK 991
-
 Aspergillus fumigatus
2.4.1.34 MK 991
-
 Candida albicans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.34 protoplast
-
 Candida albicans
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.34 Aspergillus fumigatus
-
-
-
2.4.1.34 Candida albicans
-
-
-
2.4.1.34 Neurospora crassa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.34
-
 Candida albicans
2.4.1.34
-
 Aspergillus fumigatus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.34 0.00126
-
-
 Candida albicans
2.4.1.34 0.0048
-
-
 Aspergillus fumigatus

Storage Stability

EC Number Storage Stability Organism
2.4.1.34 -70°C, more than 25 weeks 100% activity Candida albicans
2.4.1.34 -70°C, more than 26 weeks 100% activity Aspergillus fumigatus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.34 UDPglucose + (1,3-beta-D-glucosyl)n
-
 Neurospora crassa UDP + (1,3-beta-D-glucosyl)n+1
-
 ?
2.4.1.34 UDPglucose + (1,3-beta-D-glucosyl)n
-
 Candida albicans UDP + (1,3-beta-D-glucosyl)n+1
-
 ?
2.4.1.34 UDPglucose + (1,3-beta-D-glucosyl)n
-
 Aspergillus fumigatus UDP + (1,3-beta-D-glucosyl)n+1
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.4.1.34 4
-
 half life: 2.8 h Candida albicans
2.4.1.34 4
-
 half life: 5 d Aspergillus fumigatus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.34 8
-
-
 Candida albicans
2.4.1.34 8
-
-
 Aspergillus fumigatus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.1.34 6.4 8.8
-
 Aspergillus fumigatus