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Literature summary extracted from

  • Beaulieu, D.; Tang, J.; Yan, S.B.; Vessels, J.M.; Radding, J.A.; Parr, T.R., Jr.
    Characterization and cilofungin inhibition of solubilized Aspergillus fumigatus (1,3)-beta-D-glucan synthase (1994), Antimicrob. Agents Chemother., 38, 937-944.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.34 cilofungin maximal inhibition at 1.25 mM is 80%; non-competitive inhibition Aspergillus fumigatus
2.4.1.34 cilofungin non-competitive inhibition Candida albicans
2.4.1.34 Digitonin
-
 Aspergillus fumigatus
2.4.1.34 Sarkosyl
-
 Aspergillus fumigatus
2.4.1.34 Triton X-100
-
 Aspergillus fumigatus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.34 Aspergillus fumigatus
-
-
-
2.4.1.34 Candida albicans
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.34 0.0048
-
 membrane Aspergillus fumigatus
2.4.1.34 0.0096
-
 membrane plus W-1 Aspergillus fumigatus
2.4.1.34 0.0109
-
 solubilized Aspergillus fumigatus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.34 UDPglucose + (1,3-beta-D-glucosyl)n
-
 Candida albicans UDP + (1,3-beta-D-glucosyl)n+1
-
 ?
2.4.1.34 UDPglucose + (1,3-beta-D-glucosyl)n
-
 Aspergillus fumigatus UDP + (1,3-beta-D-glucosyl)n+1
-
 ?