Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Vikstrom, S.; Li, L.; Wieslander, A.
    The nonbilayer/bilayer lipid balance in membranes: Regulatory enzyme in Acholeplasma laidlawii is stimulated by metabolic phosphates, activator phospholipids, and double-stranded DNA (2000), J. Biol. Chem., 275, 9296-9302.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.208 ATP approx. 12fold stimulation at 0.75 mM, inhibition above 1.5 mM Acholeplasma laidlawii
2.4.1.208 dsDNA 0.0007 mg/ml, 7fold activation Acholeplasma laidlawii
2.4.1.208 fructose-1,6-bisphosphate 1 mM, approx. 18fold stimulation Acholeplasma laidlawii
2.4.1.208 phosphate 20 mM, 5fold stimulation in the presence of 5 mM Mg2+ Acholeplasma laidlawii
2.4.1.208 phosphatidylglycerol in vivo amounts are not enough for efficient diglucosyldiacylglycerol synthesis Acholeplasma laidlawii
2.4.1.208 phosphatidylinositol strong activation in the presence of 1,2-dioleoylphosphatidylglycerol Acholeplasma laidlawii
2.4.1.208 phosphatidylinositol-4,5-bisphosphate strong activation in the presence of 1,2-dioleoylphosphatidylglycerol Acholeplasma laidlawii
2.4.1.208 phosphoenolpyruvate 0.5 mM, 4fold stimulation, inhibition above 1.5 mM Acholeplasma laidlawii
2.4.1.208 sn-glycero-1-phosphate stimulates above 15 mM Acholeplasma laidlawii

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.208 2-phosphonooxyprop-2-enoate above 1.5 mM Acholeplasma laidlawii
2.4.1.208 ATP above 1.5 mM, stimulation below Acholeplasma laidlawii
2.4.1.208 sn-glycero-3-phosphate 20 mM, complete inhibition Acholeplasma laidlawii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.208 Mg2+ maximal activity at 10 mM, inhibition above may be due to interaction with UDP-glucose Acholeplasma laidlawii

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.208 Acholeplasma laidlawii
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.208 UDP-glucose + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
-
 Acholeplasma laidlawii UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1->2)-O-alpha-D-glucopyranosyl)-sn-glycerol
-
 ?