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Literature summary extracted from

  • Vallee, M.; Albert, C.; Beaudry, G.; Hum, D.W.; Belanger, A.
    Isolation and characterization of the monkey UDP-glucuronosyltransferase cDNA clone monUGT1A01 active on bilirubin and estrogens (2001), J. Steroid Biochem. Mol. Biol., 77, 239-249.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 UGT1A1 expressed in HK-293 cells Platyrrhini
2.4.1.17 UGT1A1 expressed in HK293 cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 5
-
 2-hydroxyestradiol
-
 Platyrrhini
2.4.1.17 6
-
 2-hydroxyestrone
-
 Platyrrhini
2.4.1.17 13
-
 estradiol
-
 Platyrrhini

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-
2.4.1.17 microsome
-
 Platyrrhini
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.17 55000
-
 UGT1 proteins by Western Blot Homo sapiens
2.4.1.17 55000
-
 UGT1 proteins by Western Blot Platyrrhini

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-
2.4.1.17 Platyrrhini
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 2-hydroxyestradiol + UDP-glucuronate
-
 Platyrrhini UDP + 2-hydroxyestradiol O-glucuronide
-
 ?
2.4.1.17 2-hydroxyestrone + UDPglucuronate
-
 Homo sapiens 2-hydroxyestrone 2-O-glucuronide + UDP
-
 ?
2.4.1.17 2-hydroxyestrone + UDPglucuronate
-
 Platyrrhini 2-hydroxyestrone 2-O-glucuronide + UDP
-
 ?
2.4.1.17 estradiol + UDPglucuronate
-
 Platyrrhini UDP + estradiol O-glucuronide
-
 ?