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Literature summary extracted from

  • Radominska-Pandya, A.; Little, J.M.; Czernik, P.J.
    Human UDP-glucuronosyltransferase 2B7 (2001), Curr. Drug Metab., 2, 283-298.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 UGT2B7 expressed in COS-1 and COS-7 cells. UGT from both UGT1A and UGT1B families expressed in colon carcinoma cells Caco-2 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information
-
 Rattus norvegicus
2.4.1.17 additional information
-
 additional information Km values for all endogenous substrates for UGT2B7 range from 0.006 to 0.1 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 endoplasmic reticulum
-
 Homo sapiens 5783
-
2.4.1.17 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
2.4.1.17 nuclear envelope
-
 Rattus norvegicus 5635
-
2.4.1.17 nuclear envelope liver and intestine Homo sapiens 5635
-
2.4.1.17 nuclear membrane liver: isoforms UGT22B7 and UGT1A6 Homo sapiens 31965
-
2.4.1.17 nucleus in liver isoforms UGT2B7 and UGT1A6 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 overview
-
2.4.1.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 adrenal gland
-
 Rattus norvegicus
-
2.4.1.17 brain
-
 Homo sapiens
-
2.4.1.17 brain
-
 Rattus norvegicus
-
2.4.1.17 colon
-
 Homo sapiens
-
2.4.1.17 jejunum
-
 Rattus norvegicus
-
2.4.1.17 kidney
-
 Homo sapiens
-
2.4.1.17 kidney
-
 Rattus norvegicus
-
2.4.1.17 liver
-
 Homo sapiens
-
2.4.1.17 liver
-
 Rattus norvegicus
-
2.4.1.17 small intestine
-
 Homo sapiens
-
2.4.1.17 small intestine
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.17 additional information
-
-
 Rattus norvegicus
2.4.1.17 additional information
-
 specific activity of several endogenous substrates by microsomal membranes for HK293 cells expressing UGT2B7 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 4-hydroxybiphenyl + UDP-glucuronate UGT2B7H and UGT2B7Y inactive Homo sapiens UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide
-
 ?
2.4.1.17 androsterone + UDPglucuronate
-
 Rattus norvegicus UDP + androsterone O-glucuronide
-
 ?
2.4.1.17 androsterone + UDPglucuronate glucuronidated by HGT2B7H and HGT2B7Y Homo sapiens UDP + androsterone O-glucuronide
-
 ?
2.4.1.17 codeine + UDPglucuronate glucuronidated by HGT2B7H and HGT2B7Y Homo sapiens codeine-6-glucuronide + UDP
-
 ?
2.4.1.17 epitestosterone + UDP-glucuronate glucuronidated by HGT2B7H and HGT2B7Y Homo sapiens UDP + epitestosterone O-glucuronide
-
 ?
2.4.1.17 estriol + UDPglucuronate
-
 Homo sapiens UDP + estriol-16 alpha-glucuronide
-
 ?
2.4.1.17 additional information Xenobiotic glucuronidation summarized Homo sapiens ?
-
 ?
2.4.1.17 additional information Xenobiotic glucuronidation summarized Rattus norvegicus ?
-
 ?
2.4.1.17 additional information 36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids Homo sapiens ?
-
 ?
2.4.1.17 morphine + UDP-glucuronate
-
 Rattus norvegicus UDP + morphine 3,6-diglucuronide
-
 ?
2.4.1.17 morphine + UDP-glucuronate glucuronidated by HGT2B7H and HGT2B7Y at 3 and 6 hydroxy positions Homo sapiens UDP + morphine 3,6-diglucuronide
-
 ?