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Literature summary extracted from

  • Tephly, T.R.
    Isolation and purification of UDP-glucuronosyltransferases (1990), Chem. Res. Toxicol., 3, 509-516.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 bilirubin stimulates the glucoronidation of 4-nitrophenol and morphine Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 different isozymes expressed in COS-7 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 4-nitrophenol glucuronide inhibits 4-nitrophenol glucuronidation Rattus norvegicus
2.4.1.17 codeine competitive inhibitor to morphine-UDPGT Rattus norvegicus
2.4.1.17 cyproheptadine
-
 Rattus norvegicus
2.4.1.17 desmethylcyproheptadine
-
 Rattus norvegicus
2.4.1.17 flunitrazepam competitive inhibitor to morphine glucuronidation Rattus norvegicus
2.4.1.17 morphine 3-glucuronide inhibits morphine glucuronidation Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 endoplasmic reticulum
-
 Homo sapiens 5783
-
2.4.1.17 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
2.4.1.17 microsome
-
 Homo sapiens
-
-
2.4.1.17 microsome
-
 Rattus norvegicus
-
-
2.4.1.17 microsome
-
 Oryctolagus cuniculus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.17 50000
-
 x * 50000, 17beta-hydroxysteroid-UDPGT Rattus norvegicus
2.4.1.17 52000
-
 x * 52000, 3alpha-hydroxysteroid-UDPGT Rattus norvegicus
2.4.1.17 53000
-
 x * 53000 estriol-UDPGT Homo sapiens
2.4.1.17 56000
-
 x * 56000, morphine-UDPGT Rattus norvegicus
2.4.1.17 56000
-
 x * 56000, 4-nitrophenol-UDPGT Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 additional information Homo sapiens elimination of lipid-soluble endogenous compounds and xenobiotics ?
-
 ?
2.4.1.17 additional information Rattus norvegicus elimination of lipid-soluble endogenous compounds and xenobiotics ?
-
 ?
2.4.1.17 additional information Oryctolagus cuniculus elimination of lipid-soluble endogenous compounds and xenobiotics ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 overview
-
2.4.1.17 Oryctolagus cuniculus
-
 rabbit
-
2.4.1.17 Rattus norvegicus
-
 overview
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.17 method Rattus norvegicus
2.4.1.17 method Oryctolagus cuniculus
2.4.1.17 two isozymes purified with chromatofocusing and UDP-hexanolamine Sepharose 4B affinity chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 estriol + UDPglucuronate
-
 Homo sapiens UDP + estriol-16 alpha-glucuronide
-
 ?
2.4.1.17 additional information elimination of lipid-soluble endogenous compounds and xenobiotics Homo sapiens ?
-
 ?
2.4.1.17 additional information elimination of lipid-soluble endogenous compounds and xenobiotics Rattus norvegicus ?
-
 ?
2.4.1.17 additional information elimination of lipid-soluble endogenous compounds and xenobiotics Oryctolagus cuniculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.17 ? x * 56000, morphine-UDPGT Rattus norvegicus
2.4.1.17 ? x * 56000, 4-nitrophenol-UDPGT Rattus norvegicus
2.4.1.17 ? x * 52000, 3alpha-hydroxysteroid-UDPGT Rattus norvegicus
2.4.1.17 ? x * 53000 estriol-UDPGT Homo sapiens
2.4.1.17 ? all values determined by SDS-PAGE Homo sapiens
2.4.1.17 ? all values determined by SDS-PAGE Rattus norvegicus
2.4.1.17 ? all values determined by SDS-PAGE Oryctolagus cuniculus
2.4.1.17 ? x * 50000, 17beta-hydroxysteroid-UDPGT Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 0.08
-
 cyproheptadine morphine-UDPGT Rattus norvegicus
2.4.1.17 1.3
-
 FNZ
-
 Rattus norvegicus
2.4.1.17 4
-
 desmethylcyproheptadine
-
 Rattus norvegicus