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Literature summary extracted from

  • Burchell, B.; Coughtrie, M.W.H.
    UDP-glucuronosyltransferases (1989), Pharmacol. Ther., 43, 261-289.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 Clofibrate induces activity of bilirubin-UDPGT Homo sapiens
2.4.1.17 Clofibrate induces activity of bilirubin-UDPGT Rattus norvegicus
2.4.1.17 Phenobarbital induces activity towards morphine, chloramphenicol, bilirubin and certain steroids Rattus norvegicus
2.4.1.17 Phenobarbital induces activities towards bilirubin and 1-naphthol whereas does not affect activities against morphine and chloramphenicol Homo sapiens
2.4.1.17 polycyclic aromatic hydrocarbons induce activity towards simple phenols such as 1-naphthol, 2-aminophenol and mitoxantrone Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expressed in COS-7 cells Rattus norvegicus
2.4.1.17 expressed in COS-7-H25 and HP1 cells Homo sapiens

General Stability

EC Number General Stability Organism
2.4.1.17 extremely unstable during purification Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 endoplasmic reticulum
-
 Homo sapiens 5783
-
2.4.1.17 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
2.4.1.17 microsome
-
 Mus musculus
-
-
2.4.1.17 microsome
-
 Homo sapiens
-
-
2.4.1.17 microsome
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.17 53000
-
 phenol-UDPGT, only isoform detectable in fetal rat liver microsomes Rattus norvegicus
2.4.1.17 53000
-
 x * 53000 by chromatofocusing and affinity chromatography on UDP-hexanolamine Sepharose 4B with estradiol as a specific substrate Homo sapiens
2.4.1.17 54000
-
 bilirubin-UDPGT, detectable after birth Rattus norvegicus
2.4.1.17 54000
-
 x * 54000 by chromatofocusing and affinity chromatography on UDP-hexanolamine Sepharose 4B with 4-aminobiphenyl as a specific substrate Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 additional information Mus musculus elimination of lipid-soluble endogenous compounds and xenobiotics ?
-
 ?
2.4.1.17 additional information Homo sapiens elimination of lipid-soluble endogenous compounds and xenobiotics ?
-
 ?
2.4.1.17 additional information Rattus norvegicus elimination of lipid-soluble endogenous compounds and xenobiotics ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 overview
-
2.4.1.17 Mus musculus
-
 mouse, overview
-
2.4.1.17 Rattus norvegicus
-
 overview
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.17 several methods including chromatofocusing, combined with anion exchange chromatography and/or affinity chromatography of UDP-hexanolamine Sepharose Rattus norvegicus
2.4.1.17 two isozymes purified with chromatofocusing and UDP-hexanolamine Sepharose 4B affinity chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 7,7,7-triphenylheptanoic acid + UDPglucuronate
-
 Rattus norvegicus UDP + 7,7,7-triphenylheptanoic acid glucuronide
-
 ?
2.4.1.17 bilirubin + UDPglucuronate Gunn strain liver enzyme inactive Rattus norvegicus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
2.4.1.17 additional information elimination of lipid-soluble endogenous compounds and xenobiotics Mus musculus ?
-
 ?
2.4.1.17 additional information elimination of lipid-soluble endogenous compounds and xenobiotics Homo sapiens ?
-
 ?
2.4.1.17 additional information elimination of lipid-soluble endogenous compounds and xenobiotics Rattus norvegicus ?
-
 ?
2.4.1.17 morphine + UDP-glucuronate
-
 Mus musculus UDP + morphine 3,6-diglucuronide
-
 ?
2.4.1.17 morphine + UDP-glucuronate
-
 Homo sapiens UDP + morphine 3,6-diglucuronide
-
 ?
2.4.1.17 morphine + UDP-glucuronate
-
 Rattus norvegicus UDP + morphine 3,6-diglucuronide
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.17 ? x * 54000 by chromatofocusing and affinity chromatography on UDP-hexanolamine Sepharose 4B with 4-aminobiphenyl as a specific substrate Homo sapiens
2.4.1.17 ? x * 53000 by chromatofocusing and affinity chromatography on UDP-hexanolamine Sepharose 4B with estradiol as a specific substrate Homo sapiens
2.4.1.17 ? all values determined by SDS-PAGE Mus musculus
2.4.1.17 ? all values determined by SDS-PAGE Homo sapiens
2.4.1.17 ? all values determined by SDS-PAGE Rattus norvegicus