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Literature summary extracted from

  • Götze, W.; Grube, E.; Rao, G.S.; Rao, M.L.; Breuer, H.
    Steroid glucuronyltransferases. II. Solubilization, purification aand kinetic properties of oestradiol-17 3-glucuronyltransferase from the microsomal fraction of pig intestine (1971), Hoppe-Seyler's Z. Physiol. Chem., 352, 1223-1230.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 estradiol
-
 Sus scrofa
2.4.1.17 estrone competitive to estradiol-17beta Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information
-
 Sus scrofa
2.4.1.17 0.046
-
 estradiol-17beta range between 0.045 mM and 0.047 mM Sus scrofa
2.4.1.17 0.22
-
 UDPglucuronic acid
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Sus scrofa
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.17 52000
-
 UGT2B7 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.17
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 small intestine
-
 Sus scrofa
-

Storage Stability

EC Number Storage Stability Organism
2.4.1.17 -20°C, stable Sus scrofa
2.4.1.17 0°C, 14 days, 80% loss of activity Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 estradiol-17alpha + UDPglucuronate
-
 Sus scrofa UDP + 17-alpha-estradiol O-glucuronide
-
 ?
2.4.1.17 estradiol-17beta + UDPglucuronate
-
 Sus scrofa estradiol-17beta-3-monoglucuronide + UDP
-
 ?
2.4.1.17 estriol + UDPglucuronate
-
 Sus scrofa UDP + estriol-16 alpha-glucuronide
-
 ?
2.4.1.17 estrone + UDPglucuronate
-
 Sus scrofa UDP + estrone 3-O-glucuronide
-
 ?

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.4.1.17 50
-
 increase of activity up to 50°C, half-life at 50°C: 15 min Sus scrofa

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.4.1.17 37
-
 stable up to Sus scrofa
2.4.1.17 50
-
 half-life 15 min Sus scrofa
2.4.1.17 62
-
 complete inactivation Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7
-
 estradiol-17-beta, Tris/maleate or phosphate buffer Sus scrofa
2.4.1.17 7.6
-
 estradiol-17beta as substrate, Tris/HCl buffer Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 0.005
-
 estradiol
-
 Sus scrofa