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Literature summary extracted from

  • Zakim, D.; Goldenberg, J.; Vessey, D.A.
    Effects of metals on the properties of hepatic microsomal uridine diphosphate glucuronyltransferase (1973), Biochemistry, 12, 4068-4074.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 UDP-N-acetylglucosamine
-
 Rattus norvegicus
2.4.1.17 UDP-N-acetylglucosamine activation in presence of divalent metal ions Cavia porcellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 EDTA decreases rate of glucuronidation if enzyme is stimulated by UDP-N-acetylglucosamine and divalent metal ions Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Cavia porcellus
-
-
2.4.1.17 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Ca2+
-
 Rattus norvegicus
2.4.1.17 Ca2+ activation in presence of UDP-N-acetylglucosamine Cavia porcellus
2.4.1.17 Co2+
-
 Rattus norvegicus
2.4.1.17 Co2+ activation in presence of UDP-N-acetylglucosamine Cavia porcellus
2.4.1.17 Cu2+
-
 Rattus norvegicus
2.4.1.17 Cu2+ activation in presence of UDP-N-acetylglucosamine Cavia porcellus
2.4.1.17 Mg2+
-
 Rattus norvegicus
2.4.1.17 Mg2+ activation in presence of UDP-N-acetylglucosamine Cavia porcellus
2.4.1.17 Mn2+ increase of glucuronidation of 4-nitrophenol and 2-aminobenzoate Cavia porcellus
2.4.1.17 Zn2+
-
 Rattus norvegicus
2.4.1.17 Zn2+ activation in presence of UDP-N-acetylglucosamine Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Cavia porcellus
-
 domestic guinea pig
-
2.4.1.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Cavia porcellus
-
2.4.1.17 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 2-aminobenzoate + UDPglucuronate
-
 Cavia porcellus UDP + ?
-
 ?
2.4.1.17 2-aminophenol + UDPglucuronate
-
 Cavia porcellus UDP + (2-aminophenyl)-O-glucuronide
-
 ?
2.4.1.17 2-aminophenol + UDPglucuronate
-
 Rattus norvegicus UDP + (2-aminophenyl)-O-glucuronide
-
 ?
2.4.1.17 4-nitrophenol + UDP-glucuronate
-
 Cavia porcellus 4-nitrophenyl beta-D-glucuronide + UDP
-
 ?
2.4.1.17 4-nitrophenol + UDP-glucuronate
-
 Rattus norvegicus 4-nitrophenyl beta-D-glucuronide + UDP
-
 ?