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Literature summary extracted from

  • Haumont, M.; Magdalou, J.; Lafaurie, C.; Ziegler, J.M.; Siest, G.; Colin, J.N.
    Phenobarbital inducible UDP-glucuronosyltransferase is responsible for glucuronidation of 3-azido-3-deoxythymidine: characterization of the enzyme in human and rat liver microsomes (1990), Arch. Biochem. Biophys., 281, 264-270.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 p-[di-n-Propylsulfamoyl]benzoic acid i.e. probenecid Homo sapiens
2.4.1.17 p-[di-n-Propylsulfamoyl]benzoic acid i.e. probenecid Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 11.6
-
 3'-azido-3'-deoxythymidine
-
 Macaca mulatta
2.4.1.17 13.4
-
 3'-azido-3'-deoxythymidine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-
2.4.1.17 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-
2.4.1.17 Macaca mulatta
-
 rhesus monkey
-
2.4.1.17 Rattus norvegicus
-
 Wistar strain
-
2.4.1.17 Rattus norvegicus
-
 Gunn strain
-
2.4.1.17 Rattus norvegicus Gunn
-
 Gunn strain
-
2.4.1.17 Rattus norvegicus Wistar
-
 Wistar strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 kidney
-
 Homo sapiens
-
2.4.1.17 kidney
-
 Rattus norvegicus
-
2.4.1.17 liver
-
 Homo sapiens
-
2.4.1.17 liver
-
 Rattus norvegicus
-
2.4.1.17 liver
-
 Macaca mulatta
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.17 additional information
-
-
 Rattus norvegicus
2.4.1.17 additional information
-
 kidney microsomes show a lower activity than liver microsomes for glucuronidation of 3'-azido-3'-deoxythymidine Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 3'-azido-3'-deoxythymidine + UDP-alpha-D-glucuronate
-
 Macaca mulatta 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
 ?
2.4.1.17 3'-azido-3'-deoxythymidine + UDPglucuronate
-
 Homo sapiens 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
 ?
2.4.1.17 3'-azido-3'-deoxythymidine + UDPglucuronate
-
 Rattus norvegicus 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
 ?
2.4.1.17 3'-azido-3'-deoxythymidine + UDPglucuronate
-
 Rattus norvegicus Gunn 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
 ?
2.4.1.17 3'-azido-3'-deoxythymidine + UDPglucuronate
-
 Rattus norvegicus Wistar 3'-azido-3'-deoxythymidine 5'-O-glucuronide + UDP
-
 ?