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Literature summary extracted from

  • Green, M.D.; Falany, C.N.; Kirkpatrick, R.B.; Tephly, T.R.
    Strain differences in purified rat hepatic 3alpha-hydroxysteroid UDP-glucuronosyltransferase (1985), Biochem. J., 230, 403-409.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.006
-
 androsterone 3alpha-hydroxysteroid UDP-glucuronosyltransferase, Wistar strain Rattus norvegicus
2.4.1.17 0.009
-
 androsterone 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity, Sprague-Dawley strain Rattus norvegicus
2.4.1.17 0.012
-
 testosterone 17beta-hydroxysteroid UDP-glucuronosyltransferase activity, Wistar strain Rattus norvegicus
2.4.1.17 0.013
-
 testosterone 17beta-hydroxysteroid UDP-glucuronosyltransferase activity, Sprague-Dawley strain Rattus norvegicus
2.4.1.17 0.02
-
 testosterone 17beta-hydroxysteroid UDP-glucuronosyltransferase activity, Wistar strain Rattus norvegicus
2.4.1.17 0.12
-
 androsterone 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity, Wistar strain Rattus norvegicus
2.4.1.17 0.3
-
 UDPglucuronate
-
 Rattus norvegicus
2.4.1.17 2
-
 4-nitrophenol no difference between Sprague-Dawley and Wistar strains Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.17 50000
-
 x * 50000, 17-beta-hydroxysteroid UDPglucuronosyl transferase activity Rattus norvegicus
2.4.1.17 52000
-
 x * 52000, 3-alpha-hydroxysteroid UDPglucuronosyl transferase activity Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Rattus norvegicus
-
 Wistar strain
-
2.4.1.17 Rattus norvegicus Wistar
-
 Wistar strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.17 additional information
-
 comparison of activities between different rat strains Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 4-nitrophenol + UDP-glucuronate
-
 Rattus norvegicus 4-nitrophenyl beta-D-glucuronide + UDP
-
 ?
2.4.1.17 4-nitrophenol + UDP-glucuronate
-
 Rattus norvegicus Wistar 4-nitrophenyl beta-D-glucuronide + UDP
-
 ?
2.4.1.17 androsterone + UDPglucuronate
-
 Rattus norvegicus UDP + androsterone O-glucuronide
-
 ?
2.4.1.17 androsterone + UDPglucuronate
-
 Rattus norvegicus Wistar UDP + androsterone O-glucuronide
-
 ?
2.4.1.17 chenodeoxycholic acid + UDP-glucuronate
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.17 chenodeoxycholic acid + UDP-glucuronate
-
 Rattus norvegicus Wistar UDP + ?
-
 ?
2.4.1.17 testosterone + UDPglucuronate
-
 Rattus norvegicus UDP + testosterone O-glucuronide
-
 ?
2.4.1.17 testosterone + UDPglucuronate
-
 Rattus norvegicus Wistar UDP + testosterone O-glucuronide
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.17 ? all values determined by SDS-PAGE Rattus norvegicus
2.4.1.17 ? x * 50000, 17-beta-hydroxysteroid UDPglucuronosyl transferase activity Rattus norvegicus
2.4.1.17 ? x * 52000, 3-alpha-hydroxysteroid UDPglucuronosyl transferase activity Rattus norvegicus